Fig. 60.2. Structural diversity of the major gammaherpesvirus signaling proteins.

Fig. 60.2

Structural diversity of the major gammaherpesvirus signaling proteins. The HVS oncoproteins Stp, Tip, or HVA Tio, the KSHV K1 and K15, RRV R1 proteins are shown along with the EBV LMP1, LMP2a. CSKH, C-terminal Src kinase homology region. ITAM, immunoreceptor tyrosine-containing activation motif. SH3b, domain interacting with src-family kinase SH3 domain. SH2b, domain interacting with src-family kinase SH2 domain. S-rich, Serine rich motif. TRAF, potential binding site for TNF-R associated factors. Y and YY, tyrosine and double-tyrosine residues, putative signaling motifs. Black, Transmembrane domain. N or C, amino- or carboxyterminus of the protein, respectively.

From: Chapter 60, Gammaherpesviruses of New World primates

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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