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Fig. 56.3. (a) The kaposin locus.

Fig. 56.3

(a) The kaposin locus. Top line, sequence organization of the gene,showing open reading frame (IRF) K12 and the upstream series of tandem direct repeats (DRs) of 23 GC- rich bp. The locus comprises two sets of such Drs(DR1 and DR2) which differ in sequence from each other. Kaposins B and C are derived from translation of the repeats via initiation from CUG codons in different reading frames; kaposin B is encoded solely by the repeats, while kaposin C extends into ORF K12. Sequence differences between different isolates of KSHV result in the production of kaposins B and C from CUGs located at different locations in the locus; shown here to illustrate this is the coding arrangement in KSHV cloned from BCBL-1PEL cells (top), and a primary KS tumor from lung tissue(bottom). (b) Schematic illustration of the p38/MK2 pathway. Activation of p38 via inflammatory or others stresses leads to its nuclear import, where it binds and phoyphorylates MK2 can phosphorylate some nuclear transcription factors. Active MK2-p38 complexes can also be exported from the nucleus to the cytosol, where MK2-p38 complexes can also be exported from the nucleus to the cytosol, where MK@ can phosphorylate additional targets involved in stabilizaton of transcripts bearing AU-rich elements (AREs). Such AREs are typically found in cytokine mRNAs. Kaposin B binds and activates MK2 in a fashion that is independent of upstream inflammatory or oxidative stresses.

From: Chapter 56, KSHV-induced oncogenesis

Cover of Human Herpesviruses
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis.
Arvin A, Campadelli-Fiume G, Mocarski E, et al., editors.
Cambridge: Cambridge University Press; 2007.
Copyright © Cambridge University Press 2007.

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