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Cover of Probe Reports from the NIH Molecular Libraries Program

Probe Reports from the NIH Molecular Libraries Program

The Molecular Libraries Program (MLP), a component of the NIH Common Fund, offers public sector biomedical researchers access to the large-scale screening capacity necessary to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease.

The Molecular Libraries Probe Production Centers Network (MLPCN), as part of the MLP, is a nationwide consortium of small molecule centers that produces innovative chemical tools for use in biological research. The MLPCN solicits novel assays from the research community for high throughput screening (HTS) against a library of 350,000 chemically diverse small molecules maintained in a central repository (the Molecular Libraries Small Molecule Repository; MLSMR). Validated screening hits are optimized by medicinal chemistry to produce useful in vitro chemical probes. All of the results from the MLPCN’s activities are deposited into an open access database, PubChem, for use in studying biology and disease.

The MLPCN brings together over 100 experienced medicinal chemists from five academic institutions and one NIH intramural center to focus on the development of high quality probes from screening hits. The lead medicinal chemists have extensive industrial experience from both biotech and large pharmaceutical companies. MLPCN probes cover highly diverse targets, biology and disease areas with many probes moving on as potential leads in drug discovery efforts after exiting the MLPCN.

This book brings together structure and biological information on the probes produced by the MLPCN in collaboration with the investigators who provided the screening assays. This information will be periodically updated with new probe information from the active MLPCN Centers.

Contents

Bookshelf ID: NBK47352PMID: 21433368
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