Table 7

Subgroup analysis by elderly and non-elderly adult patients

Mean difference (95% confidence interval)
Sleep latency in minutesSleep duration in minutesNumber of awakeningsWASO in minutes
Eszopiclone compared with ramelteonAdults
Elderly
−14.1 (−29.7 to 1.4)
−5.1 (−25.1 to 14.9)
26.4 (−40.5 to 93.3)
29.5 (0.8 to 58.2)a
--−6.4 (−22.5 to 9.7)
--
Eszopiclone compared with zaleplonAdults
Elderly
−6.8 (−17.4 to 3.8)
3.3 (−31.8 to 38.4)
23.1(−4.6 to 50.8)
13.1 (−39.7 to 65.9)
0.1 (−1.5 to 1.6)
--
--
Eszopiclone compared with zolpidemAdults
Elderly
1.6 (−11.0 to 14.2)
0.6 (−22.3 to 23.5)
7.2 (−28.9 to 43.4)
32.8 (1.2 to 64.4)
−0.6 (−1.1 to −0.2)
--
4.3 (−36.5 to 45.0)
--
Ramelteon compared with zaleplonAdults
Elderly
7.3 (−10.1 to 24.8)
8.4 (−21.6 to 38.4)
−3.3 (−74.1 to 67.5)
−16.4 (−67.9 to 35.1)
----
Ramelteon compared with zolpidemAdults
Elderly
15.7 (−3.0 to 34.5)
5.7 (−8.1 to 19.5)
−19.1 (−93.6 to 55.4)
3.3 (−25.9 to 32.5)
--10.7 (−30.2 to 51.5)
--
Ramelteon compared with zopicloneAdults
Elderly
24.1 (−3.1 to 51.3)
NA
−30.7 (−110.1 to 48.6)
NA
----
Zaleplon compared with zolpidemAdults
Elderly
8.4 (−6.5 to 23.3)
−2.7 (−34.7 to 29.3)
−15.8 (−58.7 to 27.1)
19.7 (−33.4 to 72.8)
----
Zaleplon compared with zopicloneAdults Elderly16.7 (−8.0 to 41.4)
NA
−27.4 (−78.3 to 23.5)
NA
----
Zolpidem compared with zopicloneAdults
Elderly
8.3 (−17.3 to 34.0)
NA
−11.6 (−67.5 to 44.4)
NA
0.8 (0.2 to 1.5)----
a

Statistically significant results are in boldface type.

Statistically significant results are in boldface type.

From: Results

Cover of Drug Class Review: Newer Drugs for Insomnia
Drug Class Review: Newer Drugs for Insomnia: Final Report Update 2 [Internet].
Carson S, McDonagh MS, Thakurta S, et al.
Portland (OR): Oregon Health & Science University; 2008 Oct.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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