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Norris S, Weinstein J, Peterson K, et al. Drug Class Review: Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers: Final Report [Internet]. Portland (OR): Oregon Health & Science University; 2010 Jan.

Cover of Drug Class Review: Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers

Drug Class Review: Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers: Final Report [Internet].

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Appendix EBlack box warnings for included drugs

Trade nameActive ingredientBlack box warnings
Tekturna®AliskirenWhen used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. When pregnancy is detected, drug should be discontinued as soon as possible.
Lotensil®Benazepril
Capoten®Captopril
Vasotec®Enalapril
Monopril®Fosinopril
Prinivil®Lisinopril
Zestril®Lisinopril
Univasc®Moexipril
Accupril®Quinapril
Altace®Ramipril
Aceon®Perindopril
Mavik®Trandolapril
Cozaar®Losartan
Micardis®Telmisartan
Atacand®Candesartan
Teveten®Eprosartan
Avapro®Irbesartan
Benicar®Olmesartan
Rasilez®AliskirenDrugs that act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and death when administered to pregnant women. When pregnancy is detected, Rasilez should be discontinued as soon as possible.
Inhibace®CilazaprilWhen used in pregnancy, these drugs can cause injury or even death of the developing fetus. When pregnancy is detected, Inhibace should be discontinued as soon as possible.
Coversyl®Perindopril
Diovan®Valsartan
Copyright © 2009, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK47124
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