Evidence Table 22Evidence profile of diabetic nephropathy trials: Losartan compared with enalapril in adults

Quality AssessmentSummary of Findings
Results by study, Relative effectQuality of the evidence for each outcome
StudyDesignQualityInconsistencyIndirectnessImprecisionOther considerations
Overall withdrawals
Andersen 2000
N=16
RCTFairConsistentDirectImpreciseNoneNSD between groupsModerate
Lacourciere 2000
N=103
RCTFairNSD between groups
Deyneli 2006
N=26
RCTFairNSD between groups
Albumin
Andersen 2000
N=16
RCTFairConsistentDirectImpreciseNoneNSD between groupsLow
Deyneli 2006
N=26
RCTFairNSD between groups
GFR
Andersen 2000
N=16
RCTFairConsistentDirectImpreciseNoneNSD between groupsLow
Lacourciere 2000
N=103
RCTFairNSD between groups
Serum creatinine
Andersen 2000
N=16
RCTFairConsistentDirectImpreciseNoneNSD between groupsLow
Cetinkaya 2004
N=22
RCTPoorNSD between groups
Deaths or cardiovascular events
Deyneli 2006
N=26
RCTFairN/ADirectImpreciseNoneNSD between groupsVery Low
Creatinine clearance
Deyneli 2006
N=26
RCTFairN/ADirectImpreciseNoneNSD between groupsVery Low
Regression of microalbuminuria to normoalbuminuria
Tutuncu 2001
N=34
RCTFairN/ADirectImpreciseNoneNSD between groupsVery Low
Proteinuria
Cetinkaya 2004
N=22
RCTPoorN/ADirectImpreciseNoneNSD between groupsVery Low
Cough
Lacourciere 2000
N=103
RCTFairN/ADirectImpreciseNoneSignificantly lower incidenceVery Low
Overall adverse events
Lacourciere 2000
N=103
RCTFairN/ADirectImpreciseNoneNSD between groupsVery Low

From: Evidence Tables

Cover of Drug Class Review: Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers
Drug Class Review: Direct Renin Inhibitors, Angiotensin Converting Enzyme Inhibitors, and Angiotensin II Receptor Blockers: Final Report [Internet].
Norris S, Weinstein J, Peterson K, et al.
Portland (OR): Oregon Health & Science University; 2010 Jan.
Copyright © 2009, Oregon Health & Science University, Portland, Oregon.

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