Copyright © 2010, National Academy of Sciences.
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Institute of Medicine (US) Forum on Microbial Threats. Infectious Disease Movement in a Borderless World: Workshop Summary. Washington (DC): National Academies Press (US); 2010.
- Animal Husbandry
The science of breeding, feeding, and care of domestic animals; includes housing and nutrition (http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=mesh&list_uids=68000822&dopt=Full).
- Anophelines
A genus of mosquitoes that includes all mosquitoes that transmit malaria to humans (http://www.merriam-webster.com).
- Anthroponotic
Transmission from human to human and potentially from human to animal.
- Antibiotic
Class of substances that can kill or inhibit the growth of some groups of microorganisms. Used in this report to refer to chemicals active against bacteria. Originally antibiotics were derived from natural sources (e.g., penicillin from molds), but many currently used antibiotics are semisynthetic and modified with additions of man-made chemical components. See Antimicrobials.
- Antibiotic Resistance
Property of bacteria that confers the capacity to inactivate or exclude antibiotics or a mechanism that blocks the inhibitory or killing effects of antibiotics.
- Antimicrobials
Class of substances that can destroy or inhibit the growth of pathogenic groups of microorganisms, including bacteria, viruses, parasites, and fungi.
- Arboviral Diseases
Shortened form of arthropod-borne virus. Any of a group of viruses that are transmitted to humans and animals by mosquitoes, ticks, and sand flies; they include such agents as yellow fever and eastern, western, and Venezuelan equine encephalitis viruses.
- Arthralgia
(Joint pain) or stiffness without joint swelling (http://wonder.cdc.gov/wonder/help/vaers/reportable.htm).
- Arthropod
As used in this report, refers to insects and ticks, many of which are medically important as vectors of infectious diseases.
- Arthropod-borne
Capable of being transmitted by insect and tick (arthropod) vectors.
- Asymptomatic
Presenting no symptoms of disease.
- Autopsy
Systematic examination of the body of a deceased person by a qualified pathologist. The body is inspected for the presence of disease or injury; specimens of the vital organs and/or body fluids may be taken for microscopic, chemical, or other tests.
- Bacteria
Microscopic, single-celled organisms that have some biochemical and structural features different from those of animal and plant cells.
- Biological weapons
A harmful biological agent (such as a pathogenic microorganism or a neurotoxin) used as a weapon to cause death or disease usually on a large scale (http://www.merriam-webster.com).
- Biota
The animal and plant life of a given region (http://www.epa.gov/OCEPAterms/bterms.html).
- Bioterrorism
Terrorism involving use of biological warfare agents (as disease causing viruses or herbicides).
- Botulism
A rare but serious paralytic illness caused by a nerve toxin. Symptoms of botulism include double vision, blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. The illness can cause paralysis, respiratory failure, and death (http://www.fsis.usda.gov/Fact_Sheets/Frozen_Fully_Cooked_Products_&_Botulism/index.asp).
- Bushmeat
Wildlife species which are hunted in the “bush,” or forests (http://www.wcs-congo.org/01ecosystemthreats/02bushmeat/104whatisbushmeat.html).
- Chemoprophylaxis
The use of drugs or biologics taken by asymptomatic persons to reduce the risk of developing a disease (http://odphp.osophs.dhhs.gov/pubs/guidecps/text/ii_met~1.txt).
- Communicable Disease
An infectious disease transmissible (as from person to person) by direct contact with an affected individual or the individual’s discharges or by indirect means (as by a vector).
- Disease
As used in this report, refers to a situation in which infection has elicited signs and symptoms in the infected individual; the infection has become clinically apparent.
- Emerging infections
Any infectious disease that has come to medical attention within the last two decades or for which there is a threat that its prevalence will increase in the near future (IOM, 1992). Many times, such diseases exist in nature as zoonoses and emerge as human pathogens only when humans come into contact with a formerly isolated animal population, such as monkeys in a rain forest that are no longer isolated because of deforestation. Drug-resistant organisms could also be included as the cause of emerging infections since they exist because of human influence. Some recent examples of agents responsible for emerging infections include human immunodeficiency virus, Ebola virus, and multidrugresistant Mycobacterium tuberculosis, and H1N1 influenza A.
- Emerging infectious diseases
Infections that are rapidly increasing in incidence or geographic range.
- Emigration
To leave one’s usual country of residence to settle in another.
- Encephalitis
An acute inflammatory disease of the brain due to direct viral invasion or to hypersensitivity initiated by a virus or other foreign protein.
- Endemic
Present in a community or common among a group of people; said of a disease prevailing continually in a region.
- Enteric
Of, relating to, or affecting the intestines.
- Enzootic
A disease of low morbidity that is constantly present in an animal community.
- Epidemic
The condition in which a disease spreads rapidly through a community in which that disease is normally not present or is present at a low level.
- Epidemiology
Study of the distribution and determinants of health-related states or events in specified populations. Epidemiology is the basic quantitative science of public health.
- Epizootic
A disease of high morbidity that is only occasionally present in an animal community.
- Eradication
Reduction of the worldwide incidence of a disease to zero as a result of deliberate efforts (http://www.cdc.gov/mmwr/preview/mmwrhtml/su48a7.htm).
- Etiologic agent
The organism that causes a disease.
- Etiological
Of or pertaining to causes or origins (www.dictionary.com).
- Etiology
Science and study of the causes of diseases and their mode of operation.
- Extensively Drug Resistant Tuberculosis (XDR-TB)
A relatively rare type of MDR-TB. XDR-TB is defined an M. tuberculosis isolate that is resistant to isoniazid and rifampin plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin; for more information see http://www.cdc.gov/tb/pubs/tbfactsheets/mdrtb.htm).
- Flavivirus
Any of a group of arboviruses that contain a single strand of RNA, are transmitted by ticks and mosquitoes, and include the causative agents of dengue, Japanese B encephalitis, and yellow fever.
- Food Contamination
Poisonous or deleterious substances, such as chemical contaminants, which may or ordinarily render it harmful to health (http://www.fda.gov/Food/FoodSafety/FoodContaminantsAdulteration/default.htm).
- Foodborne Diseases
Disease caused by consuming contaminated foods or beverages. Many different disease-causing microbes, or pathogens, can contaminate foods, so there are many different foodborne infections. In addition, poisonous chemicals, or other harmful substances can cause foodborne diseases if they are present in food (http://www.cdc.gov/ncidod/dbmd/diseaseinfo/foodborneinfections_g.htm).
- Genomics
The study of all the genes in a person, as well as interactions of those genes with each other and with that person’s environment (http://www.cdc.gov/genomics/faq.htm).
- Globalization
The increased interconnectedness and interdependance of peoples and countries, is generally understood to include two interrelated elements: the opening of borders to increasingly fast flows of goods, services, finance, people and ideas across international borders; and the changes in institutional and policy regimes at the international and national levels that facilitate or promote such flows (http://www.who.int/trade/glossary/story043/en/index.html).
- Hantavirus
A group of viruses that cause hemorrhagic fever and pneumonia. Hantaviruses are transmitted to humans by contact direct or indirectly with the saliva and excreta of rodents such as deer mice, field mice, and ground voles.
- Heparin
A blood-thinning drug (http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM112597).
- Herd immunity
A reduction in the probability of infection that is held to apply to susceptible members of a population in which a significant proportion of the individuals are immune because the chance of coming in contact with an infected individual is less.
- Host
Animal or plant that harbors or nourishes another organism.
- Immigration
To arrive and take up permanent residence in a country other than one’s usual county of residence.
- Immune-Competence
The ability of the immune system to respond appropriately to an antigenic stimulation (http://medical-dictionary.thefreedictionary.com/immune+competence).
- Immunologically Compromised
A condition (caused, for example, by the administration of immunosuppressive drugs or irradiation, malnutrition, aging, or a condition such as cancer or HIV disease) in which an individual’s immune system is unable to respond adequately to a foreign substance.
- Incubation Period
The time from the moment of inoculation (exposure to the infecting organism) to the appearance of clinical manifestations of a particular infectious disease (http://agclass.nal.usda.gov/agt/mtwdk.exe?k=default&l=60&w=47104&n=1&s=5&t=2).
- Infection
The invasion of the body or a part of the body by a pathogenic agent, such as a microoganism or virus. Under favorable conditions the agent develops or multiplies, the results of which may produce injurious effects. Infection should not be confused with disease.
- Inoculum
Collective term for microorganisms or their parts (spores, mycelial fragments, etc.) which are capable of infection or symbiosis when transferred to a host (http://www.w3.org/1999/xlink" xlink:href="http://agclass.nal.usda.gov/agt/mtwdk.exe?k=default&l=60&w=837&n=1&s=5&t=2).
- Insectivorous Mammals (insectivores)
Small mammals (shrews and moles) with short, dense fur, five clawed toes on each foot, and small eyes and ears. As the name implies, insectivores eat many insects and their larvae, however, they also eat many other invertebrates. They are land-dwellers, burrowers, and some spend much of their life in water (http://www.dcnr.alabama.gov/watchable-wildlife/what/Mammals/Insectivores/).
- Intellectual Property
Property (as an idea, invention, or process) that derives from the work of the mind or intellect; also an application, right, or registration relating to this (http://www.merriam-webster.com/dictionary/Intellectual%20Property).
- Intermediate Host
A host which is normally used by a parasite in the course of its life cycle and in which it may multiply asexually but not sexually (http://www.merriam-webster.com/dictionary/intermediate%20host).
- International Health Regulations (IHR)
An international legal instrument that is binding on 194 countries across the globe, including all the member states of WHO. Their aim is to help the international community prevent and respond to acute public health risks that have the potential to cross borders and threaten people worldwide. The IHR, which entered into force on June 15, 2007, require countries to report certain disease outbreaks and public health events to WHO. Building on the unique experience of WHO in global disease surveillance, alert and response, the IHR define the rights and obligations of countries to report public health events, and establish a number of procedures that WHO must follow in its work to uphold global public health security (http://www.who.int/topics/international_health_regulations/en/).
- Iron Curtain
The political, military, and ideological barrier erected by the Soviet Union after World War II to seal off itself and its dependent eastern European allies from open contact with the West and other noncommunist areas (http://www.britannica.com/EBchecked/topic/294419/Iron-Curtain).
- Latency
Delay between exposure to a disease-causing agent and manifestation of the disease (onset of infectiousness) (http://www.cdc.gov/niosh/docs/2000-127/chartbk9.htm).
- Microbe
A microorganism or biologic agent that can replicate in humans (including bacteria, viruses, protozoa, fungi, and prions).
- Microbial Threat
Microbes that lead to disease in humans.
- Microbiology
A branch of biology dealing especially with microscopic forms of life.
- Migration
The regular, usually seasonal, movement of all or part of an animal population to and from a given area (http://www.britannica.com/EBchecked/topic/381854/migration).
- Mitigation
Initiatives that reduce the risk from natural and man-made hazards.
- Melamine
An industrial chemical that can cause health problems such as kidney disease (http://wwwn.cdc.gov/travel/content/in-the-news/melamine-china.aspx).
- Morbidity
Diseased condition or state.
- Mortality
The quality or state of being mortal; the number of deaths in a given time or place; the proportion of deaths to population.
- Multiple Resistance or Multi-Drug Resistance Tuberculosis (MDR-TB)
Property of bacteria that are resistant to more than one antibiotic. In this report, MDR refers to Tuberculosis that is resistant to at least two of the best anti-tuberculosis drugs, isoniazid and rifampin. These drugs are considered first-line drugs and are used to treat all individuals with tuberculosis (for more information, see http://www.cdc.gov/tb/pubs/tbfactsheets/mdrtb.htm).
- Mutation
Genetic change that can occur either randomly or at an accelerated rate through exposure to radiation or certain chemicals (mutagens) and may lead to change in structure of the protein coded by the mutated gene.
- Myalgia
Muscle pain.
- Necropsy
An autopsy performed on an animal.
- Notifiable Disease
Disease physicians are required to report to state health departments.
- Oviposit
To lay eggs, especially by means of an ovipositor (a tube in many female insects that extends from the end of the abdomen and is used to lay eggs) (http://www.thefreedictionary.com/ovipositor).
- Paleolithic Period
Ancient cultural stage, or level, of human development, characterized by the use of rudimentary chipped stone tools (http://www.britannica.com/EBchecked/topic/439507/Paleolithic-Period).
- Pandemic
Occurring over a wide geographic area and affecting an exceptionally high proportion of the population.
- Paracetamol (acetaminophen)
A drug used in the treatment of mild pain, such as headache and pain in joints and muscles, and to reduce fever. The drug inhibits prostaglandin synthesis in the central nervous system. Overdoses can cause fatal liver damage (http://www.britannica.com/EBchecked/topic/3205/acetaminophen).
- Paramyxoviridae
Important pathogens of humans and a common cause of respiratory disease in children (http://virus.stanford.edu/paramyxo/paramyxo.html). In this report, Paramyxoviridae is used to refer to the Nipah virus, a newly emerging zoonosis that causes severe disease in both animals and humans. The natural host of the virus are fruit bats of the Pteropodidae Family, Pteropus genus (http://www.who.int/csr/disease/nipah/en/index.html).
- Parasite
An organism that lives in or on and takes its nourishment from another organism. A parasite cannot live independently. Parasitic diseases include infections by protozoa, helminths, and arthropods (http://www.medterms.com/script/main/art.asp?articlekey=4769).
- Patency
In this report patency refers to the patent period—the period between acquisition of the parasite and the time when eggs, larvae, or microfilariae are shed (http://books.google.com/books?id=oKSEhVMVrJ4C&pg=PA3&lpg=PA3&dq=patency+and+parasites&source=bl&ots=Wh45JBXqGB&sig=oYApNDLeVhJ3mQZCGCqi2hNNlZE&hl=en&ei=ac1gSoqdItqBtgfEv5XRDA&sa=X&oi=book_result&ct=result&resnum=4).
- Pathogen
Organism capable of causing disease.
- Pathogenic
Capable of causing disease.
- Pathology
The branch of medicine concerned with disease, especially its structure and its functional effects on the body (http://www.biology-online.org/dictionary/Pathology).
- Phylogeny
The connections between all groups of organisms as understood by ancestor/descendant relationships (http://www.ucmp.berkeley.edu/exhibit/introphylo.html).
- Physiochemical
Of or relating to physiological chemistry.
- Prevalence
Total number of cases (new as well as previous cases) of a disease in a given population at a point in time.
- Prions
A newly discovered type of disease-causing agent, neither bacterial nor fungal nor viral, and containing no genetic material. A prion is a protein that occurs normally in a harmless form. By folding into an aberrant shape, the normal prion turns into a rogue agent. It then co-opts other normal prions to become rogue prions. They have been held responsible for a number of degenerative brain diseases, including Mad Cow disease, Creutzfeldt-Jakob disease, and possibly some cases of Alzheimer’s disease.
- Prophylaxis
Measures designed to preserve health (as of an individual or of society) and prevent the spread of disease (http://www.merriam-webster.com/dictionary/prophylaxis).
- Public Health
The art and science of dealing with the protection and improvement of community health by organized community effort and including preventive medicine and sanitary and social health.
- Quarantine
The enforced isolation or restriction of free movement imposed to prevent the spread of a contagious disease.
- Quinolones
Class of purely synthetic antibiotics that inhibit the replication of bacterial DNA; includes ciprofloxacin and fluoroquinolone.
- Radiological Agents
Materials that emit radiation that can harm living organisms (http://books.google.com/books?id=XdXpn6NH2GcC&pg=PA363&lpg=PA363&dq=radiological+agents&source=bl&ots=5CneVzp3-e&sig=Z6Y8qF9prbJx7hdI510dNRGBj_Q&hl=en&ei=edFgSpq8MaCwtgeM16zWDA&sa=X&oi=book_result&ct=result&resnum=2).
- Recombine
The process by which the combination of genes in an organism’s offspring becomes different from the combination of genes in that organism (http://www.bio-medicine.org/biology-definition/Genetic_recombination/).
- Reservoir
Any person, animal, arthropod, plant, soil, or substance (or combination of these) in which an infectious agent normally lives and multiplies, on which it depends primarily for survival, and in which it reproduces itself in such manner that it can be transmitted to a susceptible vector.
- Resistance
- Rickettsial Disease
Caused by organisms within the genus of rickettsiae. Rickettsiae comprise a group of microorganisms that phylogenetically occupy a position between bacteria and viruses (http://emedicine.medscape.com/article/968385-overview).
- Salmonella
A group of bacteria that cause typhoid fever, food poisoning, and enteric fever from contaminated food products.
- Salmonellosis
An infection with bacteria called Salmonella. Most persons infected with Salmonella develop diarrhea, fever, and abdominal cramps 12 to 72 hours after infection. The illness usually lasts 4 to 7 days, and most persons recover without treatment (http://www.cdc.gov/nczved/dfbmd/disease_listing/salmonellosis_gi.html).
- Serotype
The characterization of a microorganism based on the kinds and combinations of constituent antigens present in that organism; a taxonomic subdivision of bacteria based on the above.
- Species Barrier
Difficulty or impossibility for an infectious agent to pass from one species to another (due to differences between species) (http://www.cite-sciences.fr/lexique/definition1.php?lang=an&id_expo=15&id_habillage=28&iddef=406&idmot=179).
- Stem Cell
A cell that has the potential to develop into many different cell types in the body during early life and growth (http://stemcells.nih.gov/info/basics/basics1.asp).
- Surge Capacity
A measurable representation of a health care system’s ability to manage a sudden or rapidly progressive influx of patients within the currently available resources at a given point in time (http://www.acep.org/practres.aspx?id=29506).
- Surveillance
Used in this workshop summary to refer to data collection and recordkeeping to track the emergence and spread of disease-causing organisms such as antibiotic-resistant bacteria.
- Syndrome
A group or recognizable pattern of symptoms or abnormalities that indicate a particular trait or disease (http://www.genome.gov/glossary.cfm?key=syndrome).
- Temporal Barrier
A barrier which blocks the movement of the entire population of an organism some of the time (http://wdfw.wa.gov/hab/ahg/shrg/11-shrg_fish_passage_restoration.pdf).
- Transmission
Process by which a pathogen passes from a source of infection to a new host.
- Universal Precautions
The use of gloves, protective garments, and masks, when handling potentially infectious or contaminated materials (http://www.who.int/csr/disease/hepatitis/whocdscsrlyo20022/en/index5.html#guidelines).
- Vaccine
A preparation of living, attenuated, or killed bacteria or viruses, fractions thereof, or synthesized or recombinant antigens identical or similar to those found in the disease-causing organisms, that is administered to raise immunity to a particular microorganism.
- Vector
A carrier, especially an arthropod, that transfers an infective agent from one host (which can include itself) to another.
- Vector-borne
Transmitted from one host to another by a vector.
- Viral Sovereignty
Deadly viruses are the sovereign property of individual nations even though they cross borders and could pose a pandemic threat to all the world’s peoples. Coined by Indonesia’s minister of health, Siti Fadilah Supari (http://www.whothailand.org/LinkFiles/Media_AI25Sep08.pdf).
- Viremia
The presence of virus in the blood of a host.
- Virulence
The ability of any infectious agent to produce disease. The virulence of a microoganism (such as a bacterium or virus) is a measure of the severity of the disease it is capable of causing.
- Wheat Gluten
The mixture of proteins, including gliadins and glutelins, found in wheat grains, which are not soluble in water and which give wheat dough its elastic texture (http://www.thefreedictionary.com/gluten).
- Xenotransplantation
Any procedure that involves the transplantation, implantation, or infusion into a human recipient of either (a) live cells, tissues, or organs from a nonhuman animal source, or (b) human body fluids, cells, tissues or organs that have had ex vivo contact with live nonhuman animal cells, tissues or organs (synonym: xenogeneic transplantation) (http://www.fda.gov/BiologicsBloodVaccines/Xenotransplantation/default.htm).
- Zoonotic Infection
Infection that causes disease in human populations but can be perpetuated solely in nonhuman host animals (e.g., bubonic plague); may be enzootic or epizootic.
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