Table D1gNasopharyngeal cancer, salivary flow

StudyRec#No. PtsSettingGroup% Stage 0/I/II% Stage III/IVMos Post-RTStimulated Flow Ratio % of BaselineUnstimulated Flow Ratio % of BaselineComments
RT
IMRT vs 2DRT
Pow, 2006 (RCT)234045RTIMRT
2DRT
IMRT
2DRT
IMRT
2DRT

IMRT
2DRT
IMRT
2DRT
IMRT
2DRT
100
100
0
0
SWS
2
2
6
6
12
12

SPS
2
2
6
6
12
12
(calculated)
0.14
0.08
0.19
0.04
0.26
0.06

0.28
0
0.57
0
1.28
0
NRSaliva stimulated by chewing on sterile rubber tubing. SWS collected 5 min in cup; SPS collected 15 min w/Lashley cup & suction over parotid duct on one side.

SWS: 2DRT vs IMRT, p < 0.003 at 2, 6, 12 mos (ANOVA)

SPS: 2DRT vs IMRT, p < 0.002 at 2, 6, 12 mos (ANOVA)

SEE IF INFO ON DOSE-SLOW FOR THIS AND PREVIOUS ARTICLE
Wu, 20054520380RT2DRT
IMRT
14.2 (all)85.8 (all)% w/↓ in parotid

82
70
For static secretion function (rated as a decrease if flow < 0.3 mL/min, i.e., no baseline measure), p < 0.05 CF, LCAF vs IMRT for percentage pts decreased post-RT. Measured 3 hrs after last food or mouthwash, then removed from parotid gland w/catheter for 15 min.
Mixed Settings
IMRT vs 2DRT
Kam, 2007 (RCT)53056RT ± ICBRTIMRT
2DRT
IMRT
2DRT
IMRT
2DRT

IMRT
2DRT
IMRT
2DRT
IMRT
2DRT
100
100
0
0
1.5
1.5
6
6
12
12

1.5
1.5
6
6
12
12
Fractional
SWSFR
0.32
0.28
0.30
0.20
0.41
0.20

Fractional
SPFR
0.39
0.09
0.70
0.04
0.90
0.05
NRMeasured amount spit out for 5 minutes after stimulated using gum for 1 min: 2DRT vs IMRT p < 0.01 at 12 mos (paired t-test).

Measured amt collected with suction cup from orifice of each parotid duct for 15 min after stimulated w/lemon candy w/fixed citric acid content: 2DRT vs IMRT p < 0.001 at 1.5, 6, 12 mos (paired t-test)

From: Appendix D, Comparative Studies: Full Evidence/Data Abstraction Tables

Cover of Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer
Comparative Effectiveness and Safety of Radiotherapy Treatments for Head and Neck Cancer [Internet].
Comparative Effectiveness Reviews, No. 20.
Samson DJ, Ratko TA, Rothenberg BM, et al.

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