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Appendix Table D5Placebo-controlled Trials of Bisphosphonates Reporting Fracture Outcomes Classified as Secondary Prevention

TrialReason for exclusion
Alendronate
Black et al, 1996239100% of enrolled patients had prior vertebral fracture
Bone et al, 19973837% of enrolled patients had prior vertebral fracture
Greenspan et al, 199846Baseline vertebral fracture not reported; 55% of enrolled patients had osteoporosis at baseline according to WHO femoral neck criteria
Greenspan et al, 20023955% of enrolled patients had prior fracture (site not specified)
Orwoll et al, 200016550% of enrolled patients had prior vertebral fracture
Ringe et al, 200416654% of enrolled patients had prior vertebral fracture
Etidronate
Ishida et al, 20044031% of enrolled patients had prior vertebral fracture
Lyritis et al, 1997240100% of enrolled patients had prior vertebral fracture
Montessori et al, 19974836% of enrolled patients with radiologic studies (78/80 patients) had prior vertebral fracture
Pacifici et al, 1988241100% of enrolled patients had prior vertebral fracture
Shiota et al, 200124260% of enrolled patients had prior vertebral fracture
Storm et al, 1990243100% of enrolled patients had prior vertebral fracture
Watts et al, 1990244100% of enrolled patients had prior vertebral fracture
Wimalawansa et al, 1998245100% of enrolled patients had prior vertebral fracture
Risedronate
Clemmesen et al, 1997246100% of enrolled patients had prior vertebral fracture
Fogelman et al, 20004529% of enrolled patients had prior vertebral fracture
Harris et al, 199924780% of enrolled patients had prior vertebral fracture
McClung et al, 20014141% of enrolled patients had prior vertebral fracture among patients with baseline fracture data (2799/6876; 2455/9331 baseline fracture status unknown)
Reginster et al, 2000248100% of enrolled patients had prior vertebral fracture
Ibandronate
Chesnut et al, 2005167100% of enrolled patients had prior vertebral fracture
Recker et al, 200416854% of enrolled patients had prior vertebral fracture
Zoledronic acid
Black et al, 200717463% of enrolled patients had prior vertebral fracture
Lyles et al, 2007175100% of enrolled patients had prior hip fracture

From: Appendix D, Appendix Tables

Cover of Screening for Osteoporosis
Screening for Osteoporosis: Systematic Review to Update the 2002 U.S. Preventive Services Task Force Recommendation [Internet].
Evidence Syntheses, No. 77.
Nelson HD, Haney EM, Chou R, et al.

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