FIGURE 4-6. Flagellar Motor Self-Assembly.

FIGURE 4-6Flagellar Motor Self-Assembly

The flagellar apparatus is assembled within the cell wall with the filament extending outside the cell. Self-assembly of this complex structure is aided by the just-in-time expression, production, and secretion of the numerous protein components as they become required for the assembly. The assembly is regulated by multiple feedback loops that control the order of protein secretion. Switching off the supply of components determines the length of the rod, the hook, and the filament shown in the figure. Quantitative characterization of biological self-assembly in model systems such as the flagella will uncover the mechanisms of assembly of complex structures and their evolution. SOURCE: Adapted from Chevance and Hughes, 2008; reprinted and adapted with permission from Macmillan Publishers Ltd.

From: 4, Common Themes at the Intersection of Biological and Physical Sciences

Cover of Research at the Intersection of the Physical and Life Sciences
Research at the Intersection of the Physical and Life Sciences.
National Research Council (US) Committee on Research at the Intersection of the Physical and Life Sciences.
Washington (DC): National Academies Press (US); 2010.
Copyright © 2010, National Academy of Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.