FIGURE B-3. The immune responses in the brain are a critical part of homeostasis but when chronically activated may contribute to the evolution of brain pathology.

FIGURE B-3The immune responses in the brain are a critical part of homeostasis but when chronically activated may contribute to the evolution of brain pathology.

Neurons and glia express receptors and ligands in the TNF superfamily (A). In the presence of inflammatory stimuli such as Aβ, oxidation and select cytokines would be predicted to be up-regulated (B) and thus would make cells at risk for activating pro-apoptotic mechanisms similar to that reported in the aging immune system.

From: B, Homeostatic Processes in Brain Aging: The Role of Apoptosis, Inflammation, and Oxidative Stress in Regulating Healthy Neural Circuitry in the Aging Brain

Cover of The Aging Mind
The Aging Mind: Opportunities in Cognitive Research.
National Research Council (US) Committee on Future Directions for Cognitive Research on Aging; Stern PC, Carstensen LL, editors.
Washington (DC): National Academies Press (US); 2000.
Copyright © 2000, National Academy of Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.