TABLE 4-1Summary of Toxicity Studies

CAS No.GroupAcuteSubacute or SubchronicChronicIrritationDevelopmental, ReproductivePharmacokineticImmunologicalCytotoxicity, MutagenicityBiocompatibility
541-05-9 D3IA3323
556-67-2 D4aIA8151151239
541-02-6 D51A912122161
541-02-61A11
540-97-6 D61A211
Mixturea113
107-46-0lB216183
107-51-7lB121
141-62-8lB12212
Mixture1
141-63-91C232111
677-62-90-71C1
69430-24-61C1
68037-74-11C11
70131-67-8a1C1113251
63148-62-9a1C5245988661919415
2554-06-5II211
546-56-5II13
2374-14-3II967
68037-59-2III2
67762-94-1III112
680-83-14-7III31
Mixture2
999-97-3IV111
2627-95-4IV811
Others3
Totalb14995161167539309316
a

Denotes human data are available.

b

Sum of all studies: 629.

From: 4, Silicone Toxicology

Cover of Safety of Silicone Breast Implants
Safety of Silicone Breast Implants.
Institute of Medicine (US) Committee on the Safety of Silicone Breast Implants; Bondurant S, Ernster V, Herdman R, editors.
Washington (DC): National Academies Press (US); 1999.
Copyright © 2000, National Academy of Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.