Evidence Table 18Characteristics of studies of Factor V Leiden and prothrombin G20210A in pregnant family members


Reference List
  1. Martinelli I, Legnani C, Bucciarelli P, Grandone E, De Stefano V, Mannucci PM. Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophilia. Thromb Haemost 2001; 86(3):800–3.
  2. Middeldorp S, Libourel EJ, Hamulyak K, Van der Meer J, Buller HR. The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden. Br J Haematol 2001; 113(2):553–5.
  3. Tormene D, Simioni P, Prandoni P et al. Factor V Leiden mutation and the risk of venous thromboembolism in pregnant women. Haematologica 2001; 86(12):1305–9.
  4. Couturaud F, Kearon C, Leroyer C et al. Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden. Thromb Haemost 2006; 96(6):744–9.
    Notes: CORPORATE NAME: Groupe d’Etude de la Thrombose de Bretagne Occidentale (G.E.T.B.O)
  5. Tormene D, De Stefano V, Grandone E et al. The G20210A prothrombin variant and the risk of venous thromboembolism or fetal loss in pregnant women: a family study. J Thromb Haemost 2007; 5(11):2193–6.
  6. Martinelli I, Battaglioli T, De Stefano V et al. The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210A. J Thromb Haemost 2008; 6(3):494–8.
    Notes: CORPORATE NAME: GIT (Gruppo Italiano Trombofilia)

From: Appendix G, Evidence Tables

Cover of Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism
Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism.
Evidence Reports/Technology Assessments, No. 180.
Segal JB, Brotman DJ, Emadi A, et al.

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