Table 9Pooled results describing the risk of VTE for family members of probands with VTE, comparing those with a mutation to those without a mutation

MutationStudies, NStudies With Data Appropriate for the Pooled Odds Ratio, nIndividuals Contributing to the Pooled Odds Ratio*, nPooled Odds Ratio [95% CI]
Heterozygous FVL962,0913.5 [2.5 to 5.0]
Homozygous FVL6589618 [7.8 to 40]
Mixed FVL6638312.9 [1.8 to 4.8]
Double Heterozygous FVL and PT 20210A437276.7 [2.9 to 15]
Mixed PT 20210A1NANANA
Homozygous PT 20210A1NANANA
Heterozygous PT 20210A332911.9 [0.35 to 10]
*

Studies without comparison groups or having zero events in both arms not included

Unadjusted odds ratios, relative to family members without mutations

CI = confidence interval; FVL = Factor V Leiden; NA = not applicable; PT 20210A = prothrombin G20210A; VTE = venous thromboembolism

Studies without comparison groups or having zero events in both arms not included

Unadjusted odds ratios, relative to family members without mutations

From: 3, Results

Cover of Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism
Outcomes of Genetic Testing in Adults with a History of Venous Thromboembolism.
Evidence Reports/Technology Assessments, No. 180.
Segal JB, Brotman DJ, Emadi A, et al.

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