Table 2.5

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and NNAL-glucuronide (NNAL-Gluc*) in the urine of nonsmokers exposed to secondhand smoke

StudyPopulationAnalyteCorrelation with cotinineMean ± standard deviation pmol/mL (number of samples analyzed)Range (fold)
Hecht et al. 1993 Men exposed to secondhand smoke in a chamberNNAL plus
NNAL-Gluc
Yes0.16 ± 0.10§ (n = 7)0.084–0.296 (4)
Parsons et al. 1998 Hospital workersNNAL-GlucYes0.059 ± 0.028 (n = 27)0.005–0.11 (22)
Meger et al. 2000 Nonsmokers exposed to secondhand smokeNNAL plus
NNAL-Gluc
Yes0.043 ± 0.044 (n = 16)0.0038–0.148 (39)
Anderson et al. 2001 Women married to smokersNNAL plus
NNAL-Gluc
No0.050 ± 0.068 (n = 23)0.009–0.28 (31)
Hecht et al. 2001 Elementary school-age childrenNNAL plus
NNAL-Gluc
Yes0.056 ± 0.076 (n = 74)0.004–0.373 (93)
*

NNAL-Gluc = A mixture of 4-(methylnitrosamino)-1-(3-pyridyl)-1-(O-β-D-glucopyranuronosyl) butane and 4-(methylnitrosamino)-1-(3-pyridyl-N-β-D-glucopyranuronosyl)-1-butanolonium inner salt.

pmol/mL = Picomoles per milliliter.

Detected values only.

§

Approximate, based on the assumption of 1,200 mL of urine excreted per day.

Source: Meger et al. 2000.

NNAL-Gluc = A mixture of 4-(methylnitrosamino)-1-(3-pyridyl)-1-(O-β-D-glucopyranuronosyl) butane and 4-(methylnitrosamino)-1-(3-pyridyl-N-β-D-glucopyranuronosyl)-1-butanolonium inner salt.

pmol/mL = Picomoles per milliliter.

Detected values only.

Approximate, based on the assumption of 1,200 mL of urine excreted per day.

From: 2, Toxicology of Secondhand Smoke

Cover of The Health Consequences of Involuntary Exposure to Tobacco Smoke
The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General.
Office on Smoking and Health (US).

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