Table 32Medical Screening Tests: Thyroid Levels

StudyTest TypeAbnormal CutoffADHD PatientsControlsp ValueComments
#Test Data#Test Data
Elia, Gulotta, Rose, et al. (1994) TSH6 U/mL532.34±1.08 U/mL (mean±SD)
0 of 53 had values above 5 U/mL (yield)
392.31± 0.85 mV/mL (mean±SD)Not significantNone of these values suggested the presence of global or pituitary thyroid hormone resistance in the children with ADHD.
Spencer, Biederman, Wilens, et al. (1995) TSH5 U/mL1261 of 126 had a value slightly above 5 U/mL (yield)147 normal adults1 of 147 had value slightly above 5 U/mL (yield)Not significantNone of the children with ADHD had evidence of clinical significant thyroid dysfunction.
Weiss, Stein, Trommer, et al. (1993) TSH6 U/mL2776 of 277 had values above 6 U/mL (yield)1060 of 106 had values above 6 U/mL (yield)Not givenAbnormal TSH was noted in 6 of 277 (2.2%) of children with ADHD; less than 1% of normal children have such abnormalities. No Children with ADHD had “Generalized Resistance to Thyroid Hormone” (GRTH).
Stein, Weiss, Refetoff (1995) TSH3.6 U/mL122.7±1.0 U/mL (mean±SD)
0 of 12 had values above the study’s 3.6 U/mL limit (yield)
12 with GRTH2.9±1.7 U/mL (mean±SD)

5 of 12 had values above the study’s 3.6 U/mL limit, but 0 of 12 were above the more conventional 5 U/mL limit (yield)
Not significantAll children with ADHD alone had normal thyroid function.

From: Summary of Findings

Cover of Diagnosis of Attention-Deficit/Hyperactivity Disorder
Diagnosis of Attention-Deficit/Hyperactivity Disorder.
Technical Reviews, No. 3.
Green M, Wong M, Atkins D, et al.

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