• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

TABLE 6-1Animal Welfare Considerations Associated with Disease Modelsa

Type of DiseasePotential ProblemsInterventionsOccupational Health Issues
Degenerative (Parkinson's disease, Alzheimer's disease, frontotemporal dementia)Adipsia, aphagia, tremor, incoordination, disorientationNursing careMPTP
Trauma (head and spinal cord injury, peripheral nerve repair and regeneration)Paralysis, distress, self-mutilation, seizuresNursing care, local anesthetics, analgesia, sedatives, antibiotics, anti-convulsants
Infectious disease (HIV, prions, meningitis, encephalitis)Seizures, debility, paralysis, disorientationMonitoring, antibiotics, anti-convulsantsMicrobial pathogens
Brain and spinal cord tumorsPain, paralysis, disorientation, seizuresAnalgesia, nursing care, anti-convulsantsHuman cell lines
StrokeSurgery complications, paralysis, disorientation, visual deficitsMonitoring, nursing care
Seizures (genetic, audiogenic, drug- or lesion-induced)Kindling, status epilepticus, secondary injuryMonitoring, anti-convulsantsNoise exposure (free field)
Immune-mediated (multiple sclerosis, myasthenia gravis, polymyositis)Muscle weakness, paralysisNursing care
Secondary medical conditions (diabetic neuropathy, renal or hepatic encephalopathy)Self-mutilation, disorientationNursing care
Pain (peripheral nerve damage, tissue damage, central nervous system damage)Self-mutilation, guarding, changes in locomotor activity, aggressionLocal anesthetics, analgesics, sedatives, environmental management
Psychiatric diseases (depression, schizophrenia)Learned helplessness, social withdrawalMonitoring, environmental enrichment
a

These lists are intended to be representative, not all-inclusive.

These lists are intended to be representative, not all-inclusive.

From: 6, Studies of Neural Injury and Disease

Cover of Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research.
National Research Council (US) Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research.
Washington (DC): National Academies Press (US); 2003.
Copyright © 2003, National Academy of Sciences.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.