Table 33Risk of vertebral fracture for vitamin D, relative to placebo*

Author, yearStudy durationType of fractureRisk levelNumber of fractures, vit dNumber of fractures, placeboOdds ratio (95% CI)
ALL FRACTURES
Grant, 200565 62 monthsNew fracturesHigh212/1343196/13321.09 (0.88, 1.34)
Torres, 2004213 12 monthssymptomatic fractureHigh0/410/45NC
VERTEBRAL
Grant, 200565 62 monthsClinical vertebralHigh4/13431/13321.17 (0.71, 1.95)
Ishida, 200493 24 monthsvertebralHigh11/6617/660.58 (0.25, 1.34)
HIP
Grant, 200565 62 monthsProximal femurHigh47/134341/13321.14 (0.75, 1.75)
Sato, 2005214 24 monthsHipHigh0/244/240.12 (0.01, 0.90)
WRIST
Grant, 200565 62 monthsDistal forearmHigh33/134328/13321.17 (0.71, 1.95)
Ishida, 200493 24 monthsvertebralHigh11/6617/660.58 (0.25, 1.34)
*

High-risk: 1) transplant population, or 2) study entry criteria require T score ≤-2.5, or 3) study entry criteria require≥1 fracture, or 4) ≥ 50% population has 1 or more fractures at baseline or 5) Significant neuromuscular impairment. Intermediate-risk: 1) study entry criteria require T score ≤1.5, or 2) 10–50% of population has one or more fracture at baseline, or 3) study population has chronic disease that is commonly treated with glucocorticoids or 4) in the absence of data on BMD or fractures, mean age of population > 62 years. Low-risk: 1) study entry criteria require T score ≤0.0, or 2) < 10% of population has BMD =8 g/cm2 at baseline, or 3) 0–10% of population has one or more fracture at baseline, or in the absence of data on BMD or fracture, mean age of population <62 years. Unknown risk: BMD, fracture history and age not reported as entry criteria or in baseline characteristics of population.

From: 3, Results

Cover of Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis
Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis [Internet].
Comparative Effectiveness Reviews, No. 12.
MacLean C, Alexander A, Carter J, et al.

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