Table 51

Prediction of Hemoglobin Response to Erythropoietic Stimulants Based on Use of a Baseline Serum Erythropoietin Observed to Predicted Ratio (O/P) Cutoff Value

Study (RCT unless otherwise indicated)#Patients treatedSerum erythropoietin O/P ratio cutoff testedComparison of % patients responding below cutoff vs. above
Musto 1997 (cohort)370.8p=0.001
Glimelius 1998 990.8no significant difference
Cazzola 1995 1170.8Patients with O/P ratio <cutoff more likely to respond
Boogaerts 2003 1330.9predictive only for patients with solid tumors: RR=1.9; 95% CI, 1.0–3.7; p<0.001
Littlewood 2003 5610.9no significant difference
Osterborg 1996 77N/AO/P ratio = only significant predictor in multivariate analysis: HR 0.84, p<0.01
Oberhoff 1998 101N/ANo significant correlation between O/P ratio and response

From: 3, Results

Cover of Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment
Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment [Internet].
Comparative Effectiveness Reviews, No. 3.
Seidenfeld J, Piper M, Bohlius J, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.