Table 20

Results for Symptom-Specific FACT Quality of Life Scales from Studies Comparing Epoetin or Darbepoetin to Placebo or No Treatment

StudyStudy armFollow- up (wks)N randN evaluable for QoL% not evaluableBlinded?FACT-AnFACT-GFACT anemia subscaleFACT fatigue subscaleFACT non-fatigue anemia subscale
% Change1p-value2% Change1p-value2% Change1p-value2% Change1p-value2% Change1p-value2
MEAN/MEDIAN BASELINE Hb <10 g/dl
Boogaerts 2003 Ctl1212910916NoNot givenNot given
Epo1331042211<0.0550.076, NS
Littlewood 2001 Ctl4–241248829Yes−5
Epo2511942330.004
Littlewood 2001 Ctl4–241249027−8
Epo25120020100.004
Osterborg 2002 Ctl1617310142Yes8
Epo1701053813<0.05
Osterborg 2002 Ctl16173103405
Epo170106389<0.05
Osterborg 2002 Ctl16173130251010
Epo1701332218>0.05, NS12>0.05, NS
Witzig 2005Ctl1617013918Yes0
Epo1741481500.4, NS
Witzig 2005Ctl16170140180
Epo17414815 −20.6, NS
Witzig 2005Ctl16170148131
Epo1741511360.18, NS
Hedenus 2003 Ctl1217315113Yes2
Darb 176152149NS
MEAN/MEDIAN BASELINE Hb 10 to 12 g/dl
Chang 2005 Ctl121751703No−8−11−4
Epo17516844<0.00015<0.00011<0.001
Iconomou 2003 Ctl12615510No−4
Epo61577210.022
Vansteenkiste 2002 Ctl12 wks15812819YesNot given
Darb 15612719Not given0.0193
MEAN/MEDIAN BASELINE Hb >12 g/dl
No trials
1

% change calculated as (end-baseline)/baseline; positive values indicate improved quality of life.

2

comparing %change in treatment arm to %change in control arm.

3

%change not reported; 56% of darbepoetin-treated patients and 44% of placebo-treated patients had an improved FACT-fatigue score (p=0.052); 32% of darbepoetin-treated patients and 19% of placebo-treated patients showed ≥25% improvement in FACT-fatigue score (p=0.019).

From: 3, Results

Cover of Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment
Comparative Effectiveness of Epoetin and Darbepoetin for Managing Anemia in Patients Undergoing Cancer Treatment [Internet].
Comparative Effectiveness Reviews, No. 3.
Seidenfeld J, Piper M, Bohlius J, et al.

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