TABLE 9.2

Parameters of 1S,3R ACPD-stimulated PI turnover in young and aged rats ± SEM

YoungAged
Cell-associated radioactivity (dpm)8421 ± 9877898 ± 466
Basal [3H]IP1 release (dpm)497 ± 33446 ± 31
Log EC50−5.17 ± 0.10−5.11 ± 0.08
Hill slope1.20 ± 0.181.78 ± 0.36
1S,3R ACPD EMAX a,b562 ± 27414 ± 24
a

dpm with basal dpm subtracted.

b

p < 0.05.

Source: From Nicolle et al., [5]. With permission.

dpm with basal dpm subtracted.

p < 0.05.

From: Chapter 9, Assessment of Second Messenger Function in the Hippocampus of Aged Rats with Cognitive Impairment

Cover of Brain Aging
Brain Aging: Models, Methods, and Mechanisms.
Riddle DR, editor.
Boca Raton (FL): CRC Press; 2007.
Copyright © 2007, Taylor & Francis Group, LLC.

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