• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Table 6Association of MPA outcomes with metabolites or genes

StudyAssociations
Behrend25 1997MPA, MPAG - renal function (MPA not correlation., MPAG inverse correlation., data not shown), AE/R (no association., data not shown)
Bunchman23 2001MPA, MPAG - AE/R, No associations found, but data not shown
Cantin58 2002MPA - rejection
Cattaneo18 2001MPA - rejection, kidney function; fMPA, MPA - AE
Filler73 1998MPA - diarrhea
Gajarski44 2004MPA - rejection
Gonzalez-Roncero 109 2005MPA, fMPA, MPAG, C0 and AUC - renal function: all higher in renal insufficiency than normal renal function, except MPA AUC
Johnson111 1999MPA, MPAG AUC correlation - creatine; MPA AUC correlation - albumin
Kaplan21 1999fMPA, MPAG AUC incr. in renal failure vs. function, MPA AUC same
Kuypers15 2003MPA, metabolites - AE/R, lab outcomes
Intra patient:
No association MPA, fMPA, AcMPAG, MPAG C0, Cmax, AUC - rejection, diarrhea, leukopenia
Higher AcMPAG C0, MPAG C0, AcMPAG/MPA, but not MPA in anemia (n=19) vs. not
MPA, fMPA, MPAG, AcMPAG Cmax or AUC: no difference between anemia (n=29) or leucopenia (n=12) or not
Inter-patient: No association MPA, fMPA, AcMPAG, MPAG C0, Cmax, AUC - rejection, diarrhea, leukopenia, anemia (data not shown); diarrhea, rejection not captured by AUCs, Cmax (too rare)
Correlation with GFR:
MPAG C0: r2 = -0.791
MPAG AUC: r2 = -0.709
fMPA C0: r2 = -0.791
fMPA AUC: r2 = -0.477
AcMPAG C0: r2 = -0.781
AcMPAG AUC: r2 = -0.505
MPA C0: r2 = 0.399
MPA AUC: r2= -0.039; all p<0.001
Maes16 2003MPA, metabolites. - fecal fat loss
Correlation fecal fat loss MPAG, AcMPAG, probably not MPA
Mandla R 38 2006MPA - rejection; fMPA - albumin, kidney function
Merkel U 22 2005Linear correlation. MPA C0 - creatine, MPAG C0 - creatine stronger correlation
Slight linear correlation MPA - protein, not MPAG - protein
Elevated transaminases (3 patients): MPA, MPAG concentrations similar to those without elevated transaminases
Two CMV infections: MPA, MPAG in 1st patient similar to those in patients without CMV; MPA in second (reactivated chronic) CMV patient higher than in first CMV patient
One diarrhea, no correlation to concentrations
4 rejections in 35 patients, 2 MPA concentrations in 2 acute rejections
Mogera115 1998MPA, MPAG AUC inverse correlation - GFR
Morgera116 1998MPAG AUC inverse correlation. - GFR, no difference for MPA
Naito108 2006Positive correlation MPA, MPAG C0 - creatine, stronger with CyA than Tac
Naesens79 2006MPA - liver and renal function, genes; genes - AE/R (diarrhea)
Pawinski64 2006MPA - rejection (ROC), renal function
Satoh30 2006MPA - rejection, genes; genes - AE/R (diarrhea)
Shaw20 2000MPA, fMPA, MPAG - diarrhea, renal function
No association MPA, fMPA, MPAG - diarrhea
MPAG, not MPA C0 higher in IRF
Shaw113 1998free fraction, MPAG, creatinine decrease with time, MPA increases but cannot be modeled
Sumethku32 2005MPA - AE/R
Tsaroucha24 2000MPA, MPAG - rejection (no correlation)
Weber110 1999fMPA, MPAG AUC - GFR (inverse correlation), MPA AUC increases with time, fMPA, MPAG AUCs consistent
Weber112 1998fMPA, MPAG, not MPA inverse correlation with GFR

Abbreviations: AcMPAG=Acyl Glucuronide Metabolite of Mycophenolic Acid, AE=Adverse Events, AE/R=Adverse/Rejection, AUC=Area-under-the-concentration-time curve, C0=Predose Trough Serum or Plasma Concentration, Cmax=Maximum Serum or Plasma Concentration, CMV=Cytomegalovirus, CyA=Cyclosporine, fMPA=Free Mycophenolic Acid, GFR=Glomerular Filtration Rate, IRF=Impaired Renal Function, MPA=Mycophenolic Acid, MPAG=Mycophenolic Acid Glucuronide, ROC= Receiver Operating Characteristic, TAC=Tacrolimus

From: 3, Results

Cover of Utility of Monitoring Mycophenolic Acid in Solid Organ Transplant Patients
Utility of Monitoring Mycophenolic Acid in Solid Organ Transplant Patients.
Evidence Reports/Technology Assessments, No. 164.
Oremus M, Zeidler J, Ensom MHH, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.