Table 13. Main Features and Findings on Probing Depth and Clinical Attachment Level: Trials of Other Systemic Antibiotics

Author, YearRandomization Placebo BlindedDurationNumber Completing Treatment ControlDosage and ModeTreatment Group PD Reduction (mm) Level of SignificanceTreatment Group CAL Gain (mm) Level of Significance
Chin Quee et al., 198796 R PL DB26 weeks (6 months)N: T: C:50 subjects 26 subjects 24 subjects3 tablets (750,000 IU of spiramycin and 125 mg of metronidazole), 2xday for 14 daysData NR, NSData NR, P < 0.05
Al-Joburi et al., 198945 R PL DB24 weeksN: T: C:52 subjects 28 subjects 24 subjects500 mg spiramycin 2xday for 14 daysInitial PD ≤ 3 mm: +0.42, NS Initial PD 4-6 mm: -0.40, NS Initial PD ≥ 7 mm: -0.28, NSInitial PD ≤ 3 mm: +0.92, NS Initial PD 4-6 mm: -0.22, NS Initial PD ≥ 7 mm: -0.08, NS
Bain et al., 199497 R PL DB24 weeksN: T: C:189 subjects 93 subjects 96 subjects1,500,000 IU of spiramycin “500” capsules, 2xday for 14 days+0.47, P < 0.0075+0.29, NS
Haffajee et al., 199546 R PL DB43 weeks (10 months)N: T: C:21 subjects 10 subjects 11 subjects250 mg amoxicillin with clavulanic acid 3xday for 30 days+0.29, NSData NR, NS
Ng and Bissada, 199898 R PL SB24 weeksN: T: C:16 subjects 8 subjects 8 subjects200 mg doxycycline on day 1 then 100 mg 1xday for 6 weeks-0.6, NS+1.3, P ≤ 0.05
Rooney et al., 200270 R PL DB26 weeks (6 months)N: T: C:31 subjects 16 subjects 15 subjects250 mg amoxicillin and placebo (calcium lactate tablets 3xday for 7 days, plus 0.2% chlorhexidine rinseInitial PD ≥ 6 mm: Data NR, P < 0.05Initial PD ≥ 6 mm: Data NR, NR
Smith et al., 200299 R PL DB22 weeksN: T: C:44 subjects 23 subjects 21 subjects500 mg azithromycin 1xday for 3 days at week 2Initial PD 1-3 mm: +0.14, NS Initial PD 4-5 mm: +0.52, P < 0.01 Initial PD ≥ 6 mm: +0.87, P < 0.05N/A

R, randomized; PL, placebo-controlled; DB, double-blind; SB, single blind; ; NR, not reported; N/A, not applicable because not one of the clinical measures used; NS, not significant.

From: 3, Results

Cover of Effectiveness of Antimicrobial Adjuncts to Scaling and Root Planing Therapy for Periodontitis
Effectiveness of Antimicrobial Adjuncts to Scaling and Root Planing Therapy for Periodontitis.
Evidence Reports/Technology Assessments, No. 88.
Bonito AJ, Lohr KN, Lux L, et al.

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