Table 22b. Evidence table of case reports - Cerebrovascular Accident/Stroke

Event typeProductInvestigation of EtiologyRAND Classification
Report dateDose*
Age, SexTiming; Duration
Constituent
Source
(ID)
CVAThermo SlimImplicit reviewSentinel event
01/03/1996Unknown
26 yo Female<6 hours; 2–13 days
Ephedra
FDA Case
(10874)
CVAPower TrimImplicit reviewSentinel event
04/12/1996Unknown
42 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(11062)
CVATrim EasyImplicit reviewSentinel event
04/17/199672.0 mg
31 yo Female6–24 hours; >60 days (chronic)
Ephedra
FDA Case
(11105)
CVARipped FuelImplicit reviewSentinel event
09/04/199663.6 mg
28 yo MaleNot described; >60 days (chronic)
Ephedra
FDA Case
(11675)
CVAUltimate OrangeImplicit reviewSentinel event
06/16/1998Unknown
39 yo Male<6 hours; Not described
Ephedra
FDA Case
(12980)
CVAUltimate OrangeImplicit reviewSentinel event
12/31/199862.1 mg
29 yo Male<6 hours; 14–60 days (acute)
Ephedra
FDA Case
(13418)
CVASlim CapsImplicit reviewSentinel event
09/12/200024.0 mg
53 yo Female6–24 hours; 14–60 days (acute)
Ephedra
FDA Case
(14372)
CVAXenadrineImplicit reviewSentinel event
10/20/2000Unknown
46 yo Female<6 hours; 2–13 days
Ephedra
FDA Case
(14473)
CVAThermadreneImplicit reviewSentinel event
33 yo MaleUnknown
Ephedra6–24 hours; Not described
Literature Case
(552)
CVAEphedrineImplicit reviewSentinel event
19 yo FemaleUnknown
Ephedrine<6 hours; Not described
Literature Case
(184)
CVA“Purported amphetamine look-alike”Implicit reviewSentinel event
20 yo FemaleUnknown
Ephedrine<6 hours; < 48 Hours
Literature Case
(514)
CVAE'ola Amp II Pro DropsImplicit reviewPossible sentinel event
04/17/199275.0 mgNote that this product was removed from the market- it contained illegal doses of ephedrine.
30 yo Female<6 hours; 2–13 days
Ephedra
FDA Case
(9296)
CVAE'ola Amp II Pro DropsImplicit reviewPossible sentinel event
04/22/1994UnknownNote that this product was removed from the market- it contained illegal doses of ephedrine.
56 yo Female6–24 hours; >60 days (chronic)
Ephedra
FDA Case
(9335)
CVASuper Fat BurnersImplicit reviewPossible sentinel event
03/15/1995Unknown
24 yo Female6–24 hours; <48 hours
Ephedra
FDA Case
(10094)
CVAFitAmerica Natural Weight ControlAidImplicit reviewPossible sentinel event
01/09/1998100.0 mg
64 yo Female<6 hours; >60 days (chronic)
Ephedra
FDA Case
(12713)
CVAPurple BlastImplicit reviewPossible sentinel event
12/23/1997Unknown
47 yo Male<6 hours; 14–60 days (acute)
Ephedra
FDA Case
(12733)
CVADiet PhenImplicit reviewPossible sentinel event
04/27/199813.5 mg
41 yo Female6–24 hours; 14–60 days (acute)
Ephedra
FDA Case
(12888)
CVANatural TrimImplicit reviewPossible sentinel event
09/13/200044.0 mg
25 yo Female6–24 hours; 14–60 days (acute)
Ephedra
FDA Case
(14378)
CVASlim 'N UpImplicit reviewPossible sentinel event
10/12/2000Unknown
42 yo Male6–24 hours; >60 days (chronic)
Ephedra
FDA Case
(14434)
CVA/Subarachnoid hemorrhageMetabolife 356Implicit reviewPossible sentinel event
11/16/2000Unknown
55 yo Female6–24 hours; 14–60 days (acute)
Ephedra
FDA Case
(14553)
CVAMa huangImplicit reviewPossible sentinel event
33 yo Male40 mg
Ephedra6–24 hours; 14–60 days
Literature Case
(270)
CVA“Street drug”Implicit reviewPossible sentinel event
37 yo Male153.0 mg
EphedrineNot described; 14–60 days (acute)
Literature Case
(44)
CVA“Speed”Implicit reviewPossible sentinel event
20 yo MaleUnknown
Ephedrine<6 hours; Not described
Literature Case
(438)
CVAEphedrineNot relevantIntraoperative ephedrine
29 yo FemaleUnknown
Ephedrine<6 hours; < 48 hours
FDA Case
(3720184)
CVAEphedrineNot relevantIntraoperative ephedrine
45 yo FemaleUnknown
Literature Case<6 hours; < 48 hours
(485)
CVANature's Nutrition-Formula OneImplicit reviewInsufficient information
05/12/1994Unknown
36 yo Female<6 hours; >60 days (chronic)
Ephedra
FDA Case
(9521)
CVANature's Nutrition-Formula OneNot reviewedInsufficient information
06/22/1994Unknown
52 yo MaleNot described; >60 days (chronic)
Ephedra
FDA Case
(9545)
CVAEquillizer Fast StartNot reviewedDid not meet the temporal relationship criterion
10/26/1994Unknown
40 yo Female>24 hours; 2–13 days
Ephedra
FDA Case
(9749)
CVANature's Nutrition-Formula OneNot reviewedInsufficient information
09/14/1994Unknown
49 yo MaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(9865)
CVANature's Nutrition-Formula OneNot reviewedInsufficient information
05/12/1995Unknown
53 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(10187)
CVATriChromoleanNot reviewedInsufficient information
10/19/1995Unknown
31 yo FemaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(10477)
CVAThermoburnNot reviewedInsufficient information
10/12/1995Unknown
19 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(10508)
CVAMetaboliftNot reviewedInsufficient information
02/07/199660.0 mg
30 yo FemaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(10893)
CVAE'ola Amp II Pro DropsNot reviewedInsufficient information
04/13/1996Unknown
34 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(10957)
CVANatural TrimNot reviewedInsufficient information
07/11/1996Unknown
55 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(11306)
CVAHerbalife Original GreenNot reviewedInsufficient information
07/18/1996Unknown
39 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(11442)
CVAE'ola Amp II Pro DropsNot reviewedDid not meet the temporal relationship criterion
06/18/199621.5 mg
35 yo Female>24 hours; Not described
Ephedra
FDA Case
(11619)
CVAHerbalife Original GreenNot reviewedInsufficient information
08/21/1996Unknown
33 yo FemaleNot described; >60 days (chronic)
EphedraAP300
FDA CaseUnknown
(11706)Not described; >60 days (chronic)
CVAE'ola Amp II Pro DropsNot reviewedInsufficient information
10/21/199636.8 mg
69 yo FemaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(12340)
CVAShape FastNot reviewedInsufficient information
06/05/199730.0 mg
64 yo FemaleNot described; Not described
Ephedra
FDA Case
(12460)
CVAShape FastNot reviewedInsufficient information
08/01/199736.0 mg
34 yo FemaleNot described; 2–13 days
Ephedra
FDA Case
(12483)
CVAMetabolife 356Not reviewedInsufficient information
04/22/1998Unknown
43 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(12861)
CVATotal ControlNot reviewedDid not meet the temporal relationship criterion
02/11/199966.0 mg
47 yo Female>24 hours; >60 days (chronic)
Ephedra
FDA Case
(13336)
CVAMetacutNot reviewedInsufficient information
02/01/199912.3 mg
48 yo FemaleNot described; 2–13 days
Ephedra
FDA Case
(13341)
CVAHydroxycut (Muscle Tech R&D)Not reviewedDid not meet the temporal relationship criterion
06/01/1999160.0 mg
16 yo Male>24 hours; 14–60 days (acute)
Ephedra
FDA Case
(13661)
CVAMetabolife 356Not reviewedInsufficient information
06/23/1999Unknown
18 yo FemaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(13779)
CVAMetabolife 356Not reviewedInsufficient information
08/03/1999Unknown
24 yo FemaleNot described; >60 days (chronic)
Ephedra
FDA Case
(13797)
CVAMetabolife 356Implicit reviewInsufficient information
08/04/199948.0 mg
30 yo Female<6 hours; 2–13 days
Ephedra
FDA Case
(13829)
CVAMetabolife 356Not reviewedInsufficient information
07/01/1999Unknown
26 yo FemaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(13837)
CVAMetabolife 356Implicit reviewInsufficient information
10/27/1999Unknown
36 yo Female<6 hours; >60 days(chronic)
Ephedra
FDA Case
(13905)
CVARipped FuelNot reviewedInsufficient information
10/08/1998Unknown
Not described yo FemaleNot described; Not described
Ephedra
FDA Case
(14056)
CVAMetabolife 356Not reviewedInsufficient information
06/13/2000Unknown
46 yo FemaleNot described; 14–60 days (acute)
EphedraXenadrine
FDA CaseUnknown
(14231)Not described; 14–60 days (acute)
CVASlacker IINot reviewedInsufficient information
10/03/2000Unknown
21 yo FemaleNot described; 2–13 days
Ephedra
FDA Case
(14431)
CVALiquiFit Exercise DropsNot reviewedInsufficient information
01/16/200175.0 mg
48 yo FemaleNot described; 14–60 days (acute)
Ephedra
FDA Case
(14632)
CVAEphedrine (“Maxi Thins”)Implicit reviewInsufficient information
32 yo FemaleUnknown
EphedrineNot described; >60 days (chronic)
FDA Case
(1823550)
CVA“Over-the-counter anti-asthma pill”Implicit reviewInsufficient information
68 yo Male60.0 mg
Literature Case<6 hours; >60 days (chronic)
(515 )
*

dose reported in total daily alkaloids

yo = year old

From: 3, Results

Cover of Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement
Ephedra and Ephedrine for Weight Loss and Athletic Performance Enhancement: Clinical Efficacy and Side Effects.
Evidence Reports/Technology Assessments, No. 76.
Shekelle P, Morton SC, Maglione M, et al.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.