Table 4Sensitivity of flexible sigmoidoscopy protocol for advanced neoplasia

StudyPatient CharacteristicsOverall polyp prevalenceSensitivity of FS with biopsy for advanced neoplasia in the whole colonSensitivity of FS without biopsy for advanced neoplasia in the whole colonSensitivity of FS with biopsy for CRC in the whole colonSensitivity of FS without biopsy for CRC in the whole colon
Betes Ibanez 2004144
Spain
Distal definition: descending & sigmoid colon, rectum
N: 2210
Age incl: >40; Mean age: 57.9
% Ethnic Origin:NR
% female: 25.4%
FH: NR
Any neoplasm: 28%
Adv. neoplasm: 7%
CRC: 0.5%
85.3% (133/156)NRNRNR
Ikeda 2000145
Japan
Distal definition: splenic flexure, descending & sigmoid colon, rectum
N: 3131
Age incl: 48–57; Mean age: 61.2
% Ethnic Origin: [Japanese]
% female: 0%
FH: NR
Any neoplasm:25.9%
Adv. neoplasm: 2.4%
CRC: 0.6%
73.7% (56/76)NRNRNR
Anderson 200458
USA
Distal definition: descending & sigmoid colon, rectum
N: 1988
Age incl: >40; Mean age: 57.2
% Ethnic Origin:1.5% NW
% female: 45.6%
FH: 13.6%
Any neoplasm: 21.9%
Adv. neoplasm: 10.2%
CRC:0.4%
73.8% (155/210)NR62.5% (5/8)NR
Imperiale 2003146
Imperiale 200059
USA
Distal definition: descending & sigmoid colon, rectum
N: 3025 (1994 subgroup)
Age incl: ≥50; Mean age: 58.9
% Ethnic Origin: 90% white
% female: 42%
FH: NR
Any neoplasm: NR
Adv. neoplasm: 6.0%
CRC: NR
Total: 71.8% (130/181)
Male: 70.0% (98/140)
Female: 78.0% (32/41)
76.8% (139/181)58.3%(7/12)75.0% (8/12)
Lieberman 200060
USA
Distal definition: descending & sigmoid colon, rectum
N: 3121
Age incl: 50–75; Mean age: 62.9
% Ethnic Origin: 16.4% NW
% female: 3.2%
FH: 13.9%
Any neoplasm: 37.5%
Adv. neoplasm: 10.5%
CRC: 1.0%
81.7% (272/333)85.6% (285/333)NRNR
Distal definition:
sigmoid colon, rectum
71.2%
(237/333)
78.7%
(262/333)
NRNR
Schoenfeld 200561
USA
Distal definition: descending & sigmoid colon, rectum
N: 1463
Age incl: 40–79; Mean age: 58.9
% Ethnic Origin: 23% nonwhite
% female: 100%
FH: 15.7%
Any polyps: NR
Any neoplasm: 20.4%
Advanced neoplasm: 4.9%
CRC: 0.1%
50% (36/72) NR NR NR
Distal definition:
sigmoid colon, rectum
34.7% (25/72)NRNRNR
*

This estimation of sensitivity is for flexible sigmoidoscopy with biopsy only

From: 3, Key Questions & Results

Cover of Screening for Colorectal Cancer: An Updated Systematic Review
Screening for Colorectal Cancer: An Updated Systematic Review [Internet].
Evidence Syntheses, No. 65.1.
Whitlock EP, Lin J, Liles E, et al.

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