NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Bader JD, Bonito AJ, Shugars DA. Cardiovascular Effects of Epinephrine on Hypertensive Dental Patients. Rockville (MD): Agency for Healthcare Research and Quality (US); 2002 Jul. (Evidence Reports/Technology Assessments, No. 48.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Cardiovascular Effects of Epinephrine on Hypertensive Dental Patients

Cardiovascular Effects of Epinephrine on Hypertensive Dental Patients.

Show details


Franklin SS, Jacobs MJ, Wong ND, L'Italien GJ, Lapuerta P Predominance of isolated systolic hypertension among middle-aged and elderly us hypertensives: analysis based on national health and nutrition examination survey (NHANES) III. Hypertension. 2001;37:869–74. [PubMed: 11244010]
Matsuura H The systemic management of cardiovascular risk patients in dentistry. [Review] [39 refs] Anesth Pain Control Dent. 1993;2:49–61. [PubMed: 8329905]
Meechan JG Plasma potassium changes in hypertensive patients undergoing oral surgery with local anesthetics containing epinephrine. Anesth Prog. 1997;44:106–9. [PMC free article: PMC2148929] [PubMed: 9481971]
Goulet JP, Perusse R, Turcotte JY Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions [see comments]. [Review] [51 refs] Oral Surg, Oral Med Oral Pathol. 1992;74:692–7. [PubMed: 1359489]
Glick M New guidelines for prevention, detection, evaluation and treatment of high blood pressure. J Am Dent Assoc. 1998;129:1588–1594. [PubMed: 9818576]
Muzyka BC, Glick M The hypertensive dental patient. J Am Dent Assoc. 1997;128:1109–1120. [PubMed: 9260420]
Dionne RA, Goldstein DS, Wirdzek PR Effects of diazepam premedication and epinephrine-containing local anesthetic on cardiovascular and plasma catecholamine responses to oral surgery. Anesth Analg. 1984;63:640–6. [PubMed: 6731889]
Lohr K, Carey T Assessing "best evidence": issues in grading the quality of studies for systematic reviews. Jt Comm J Qual Improv. 1999;25:470–479. [PubMed: 10481816]
Salman I, Schwartz S Effects of vasoconstrictors used in local anesthetics in patients with diseases of the heart. J Oral Surg. 1955;13:209–213. [PubMed: 14392539]
Elliott GD, Stein E Oral surgery in patients with atherosclerotic heart disease. Benign effect of epinephrine in local anesthesia. JAMA. 1974;227:1403–4. [PubMed: 4406023]
Meiller TF, Overholser CD, Kutcher MJ, Bennett R Blood pressure fluctuations in hypertensive patients during oral surgery. J Oral Maxillofac Surg. 1983;41:715–718. [PubMed: 6579257]
Yoshimura Y The relation of tooth extraction to anginal attack. J Oral Maxillofac Surg. 1983;41:365–76. [PubMed: 6574218]
Hasse AL, Heng MK, Garrett NR Blood pressure and electrocardiographic response to dental treatment with use of local anesthesia. J Am Dent Assoc. 1986;113:639–42. [PubMed: 2945853]
Hirota Y, Sugiyama K, Joh S, Kiyomitsu Y An echocardiographic study of patients with cardiovascular disease during dental treatment using local anesthesia. J Oral Maxillofac Surg. 1986;44:116–121. [PubMed: 3456017]
Salonen M, Forssell H, Scheinin M Local dental anesthesia with lidocaine and adrenaline. Effects on plasma catecholamines, heart rate and blood pressure. Int J Oral Maxillofac Surg. 1988;17:392–4. [PubMed: 3145958]
Vanderheyden PJ, Williams RA, Sims TN Assessment of ST segment depression in patients with cardiac disease after local anesthesia. J Am Dent Assoc. 1989;119:407–12. [PubMed: 2527898]
Davenport RE, Porcelli RJ, Iacono VJ, Bonura CF, Mallis GI, Baer PN Effects of anesthetics containing epinephrine on catecholamine levels during periodontal surgery. J Periodontol. 1990;61:553–8. [PubMed: 2213464]
Meechan JG, Rawlins MD The effects of two different local anaesthetic solutions administered for oral surgery on plasma potassium levels in patients taking kaliuretic diuretics. Eur J Clin Pharmacol. 1992;42:155–8. [PubMed: 1618246]
Leviner E, Tzukert AA, Mosseri M, et al Perioperative hemodynamic changes in ischemic heart disease patients undergoing dental treatment. Spec Care Dentist. 1992;12:84–8. [PubMed: 1440125]
Findler M, Mazor D, Galili D, Garfunkel A Dental treatment in a patient with malignant pheochromocytoma and severe uncontrolled high blood pressure. Oral Surg Oral Med Oral Pathol. 1993;75:290–291. [PubMed: 8097035]
Campbell RL, Langston WG A comparison of cardiac rate-pressure product and pressure-rate quotient in healthy and medically compromised patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80:145–52. [PubMed: 7552876]
Nichols C Dentistry and hypertension. J Am Dent Assoc. 1997;128:1557–62. [PubMed: 9368441]
Blinder D, Manor Y, Shemesh J, Taicher S Electrocardiographic changes in cardiac patients having dental extractions under a local anesthetic containing a vasopressor. discussion 1402-3. J Oral Maxillofac Surg. 1998;56:1399–402. [PubMed: 9846537]
Niwa H, Satoh Y, Matsuura H Cardiovascular responses to epinephrine-containing local anesthetics for dental use: a comparison of hemodynamic responses to infiltration anesthesia and ergometer-stress testing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:171–81. [PubMed: 10936836]
Phatak NM, Lang RL Systemic hemodynamic effects of R-epinephrine gingival retraction cord in clinic patients. J Oral Ther Pharmacol. 1966;2:393–8. [PubMed: 5334252]
Fritts KW, Thayer KE, Yoder JL The use of epinephrine impregnated retraction cords. J Acad Gen Dent. 1970;18:17–9. [PubMed: 5317695]
Houston JB, Appleby RC, DeCounter L, Callaghan N, Funk DC Effect of r-epinephrine-impregnated retraction cord on the cardiovascular system. J Prosthet Dent. 1970;24:373–6. [PubMed: 4195839]
Munoz RJ The cardiovascular effects of anxiety and R-epinephrine retraction cord in routine fixed prosthodontic procedures. J Calif Dent Assoc. 1970;46:10–3. [PubMed: 4913980]
Pelzner RB, Kempler D, Stark MM, Lum LB, Nicholson RJ, Soelberg KB Human blood pressure and pulse rate response to racemic epinephrine retraction cord. J Prosthet Dent. 1978;39:287–92. [PubMed: 344863]
Hatch CL, Chernow B, Terezhalmy GT, Van Ness M, Hall-Boyer K, Lake CR Plasma catecholamine and hemodynamic responses to the placement of epinephrine-impregnated gingival retraction cord. Oral Surg Oral Med Oral Pathol. 1984;58:540–4. [PubMed: 6392983]
Cheraskin E, Prasertsuntarasai T Use of epinephrine with local anesthesia in hypertensive patients: III. Effect of epinephrine on blood pressure and pulse rate. J Am Dent Assoc. 1958;57:507–519. [PubMed: 13575081]
Vernale C Cardiovascular responses to local dental anesthesia with epinephrine in normotensive and hypertensive subjects. Anesthesiology. 1960;13:942–952. [PubMed: 13841864]
Meyer FU Hemodynamic changes of local dental anesthesia in normotensive and hypertensive subjects. Int J Clin Pharmacol, Ther Toxicol. 1986;24:477–81. [PubMed: 3781681]
Abraham-Inpijn L, Borgmeijer-Hoelen A, Gortzak RA Changes in blood pressure, heart rate, and electrocardiogram during dental treatment with use of local anesthesia. J Am Dent Assoc. 1988;116:531–6. [PubMed: 3164019]
Miura K, Matsumura K, Nakamura Y, Kurokawa H, Kajiyama M, Takata Y Suppression of cardiac sympathetic nervous system during dental surgery in hypertensive patients. Hypertens Res. 2000;23:207–12. [PubMed: 10821128]
Mito RS, Yagiela JA Hypertensive response to levonordefrin in a patient receiving propranolol: report of case. J Am Dent Assoc. 1988;116:55–7. [PubMed: 3278028]
van der Bijl P, Victor AM Adverse reactions associated with norepinephrine in dental local anesthesia. Anesth Prog. 1992;39:87–9. [PMC free article: PMC2148749] [PubMed: 1308379]
Barclay JK Unusual responses to drugs: Two case reports. N Z Dent J. 1981;77:69–70. [PubMed: 6942274]
Hilley MD, Milam SB, Giescke AHJ, Giovannitti JA Fatality associated with the combined use of halothane and gingival retraction cord. Anesthesiology. 1984;60:587–8. [PubMed: 6731915]
Hondrum SO Hypertensive episode in the dental office. Gen Dent. 1985;33:134–9. [PubMed: 3858202]
Kronman JH, Giunta JL Reflex vasoconstriction following dental injections. Oral Surg Oral Med Oral Pathol. 1987;63:542–544. [PubMed: 3473373]
Gortzak RA, Abraham-Inpijn L Pain-induced hypertensive episode in the dental office. Gen Dent. 1995;43:274–6. [PubMed: 8940586]
Umino M, Ohwatari T, Shimoyama K, Nagao M Unexpected atrial fibrillation during tooth extraction in a sedated elderly patient. Anesth Prog. 1994;41:77–80. [PMC free article: PMC2148821] [PubMed: 8934964]
Sugimura M, Hirota Y, Shibutani T, et al An echocardiographic study of interactions between pindolol and epinephrine contained in a local anesthetic solution. Anesth Prog. 1995;42:29–35. [PMC free article: PMC2148851] [PubMed: 8934951]
PubReader format: click here to try


  • PubReader
  • Print View
  • Cite this Page

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...