NOTE: The larger circle denotes techniques broadly applied to treat many forms of pain regardless of site, chronicity, or etiology. Such techniques include pharmacologic (NSAIDs, opioids, adjuvants), anesthetic, and nondrug (cognitive-behavioral or physical) therapies. The smaller circle denotes treatments for cancer pain, most of which fall within the larger circle. Of those not included within the larger circle, some (shown as horizontal stripes) target specific tumor pathophysiology (e.g., neurolytic celiac plexus block, biphosphonates, gemcitabine, radionuclides, mitoxantrone). Other treatments for cancer pain (shown cross-hatched) are less closely influenced by specifics of tumor biology (e.g., external radiation). Outside of both circles may be envisaged treatment of the many other symptoms and impairments to multiple dimensions of health-related quality of life besides pain itself. The aggregate burden of pain and other symptoms and impairments is addressed by palliative and supportive care.