Part I of Evidence Table

StudySample Size & Intervention GroupsDemographics/ComorbiditiesSource of PatientsPrerandomization Evaluation & Required StenosisRequired Preoperative A-gram?
A-gram Complic. Rate
WRAMC 29 Total = 29Mean age = 63 yearsNot reportedOPGYes
ASA = 14Male72%
CEA = 15HTN69%
MACE 30 Total = 7170% > 65 yearsNot reportedOPG, U/S, or angiogramYes
ASA = 35Male56–60%
CEA = 36White
VACS 31 Total = 444Mean age 65 yearsNot reportedA-gramYes
MM = 233Male100%≥ 50%0.4%
CEA = 211White86–88%
Contralateral TIA/stroke = 32%
ACAS 32 Total = 1659Mean age = 67 yearsVascular ultrasonography laboratories, physicians who found bruits during evaluation for PVD or contralateral CEAU/S or angiogramYes
MM = 834Male66%≥ 60%1.2%
CEA = 825White94–95%
↑Chol% NR
Contralateral CEA= 20%
ACST 33 Total = 3,120Mean age = 68 yearsMedical and surgical clinicsU/SNo
MM = 1,560Male66%≥ 60%
CEA = 1,560HTN65%
Non-DM CAD27%
Contralateral CEA 24%

Five-year non-perioperative stroke;

Not statistically significantly different;

Statistically significantly different;

No significant benefit to CEA in this group;

Statistical significance between groups not reported

WRAMC = Walter Reed Army Medical Center Study; MACE = Mayo Asymptomatic Carotid Endarterectomy Study; VACS = Veterans Affairs Cooperative Study; ACAS = Asymptomatic Carotid Atherosclerosis Study; ACST = Asymptomatic Carotid Surgery Trial; NR=Not reported, MM = Medical Management; ASA = aspirin; CEA = carotid endarterectomy group; HTN = hypertension; DM = diabetes mellitus; ↑Chol = hyperlipidemia; CAD = coronary artery disease; TIA = transient ischemic attack; OPG = ocular pneumoplethysmography; U/S = ultrasound; PVD = peripheral vascular disease; MI = myocardial infarction; CI = confidence interval; RR = relative risk; ARR = absolute risk reduction; RRR = relative risk reduction; SE = standard error; W = women; M = men

From: Appendix 3. Evidence Table for Randomized Controlled Trials for Effectiveness of Surgery versus Medical Management for Asymptomatic Carotid Artery Stenosis

Cover of Screening For Asymptomatic Carotid Artery Stenosis
Screening For Asymptomatic Carotid Artery Stenosis [Internet].
Evidence Syntheses, No. 50.
Wolff T, Guirguis-Blake J, Miller T, et al.

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