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Supplemental Evidence Table E5. Treatment Results of Studies Comparing Tricyclic Antidepressants and Placebo1 Psychological Conduct/Oppositional (Scales used for test scores may vary across studies)

Author(s) &
Year of
Publication
ArmInterventionsTests UsedTest ScoresTest ScoresStatistical Significance 2 (p<0.05 rated as significant)
Arm 1 Mean ± SDArm 2 Mean ± SDArm 3 Mean ± SD
Werry 1980 1
2
3
Placebo
MPH
Imipramine
CD:
Conners parent
Conners teacher

1.0 3
1.68 3

1.04 3
1.54 3

0.78 3
1.5 3

Imipramine > MPH, Placebo; MPH vs. Placebo = NS
NS
Winsberg 1980 1
2
Placebo
Imipramine
Aggressiveness:
Conners parent
Conners teacher

2.29 ± 0.63
2.46 ± 0.74

1.98 ± 0.62
2.36 ± 0.71

NS
NS
1

Studies in this group with no data with outcomes of interest given are: Biederman 1989a,b; Donnelly 1986; Gualtieri 1991; Gualtieri 1988; Rapport 1993; Singer 1995; Wilens 1996.

2

> = better than; NS-not significant; NR-statistical significance not reported.

3

SD not given.

From: Supplemental Evidence Tables

Cover of Treatment of Attention-Deficit/Hyperactivity Disorder
Treatment of Attention-Deficit/Hyperactivity Disorder.
Evidence Reports/Technology Assessments, No. 11.
Jadad AR, Boyle M, Cunningham C, et al.

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