Supplemental Evidence Table B8. Treatment Results of Studies with Drug vs. Drug Comparisons1Inattention-Hyperactivity-Impulsivity (Scales used for test scores may vary across studies)

Author(s) & Year of PublicationArmInterventionsTests UsedTest ScoresTest ScoresStatistical Significance 2 (p<0.05 rated as significant)
Arm 1 Mean ± SDArm 2 Mean ± SDArm 3 Mean ± SDArm 4 Mean ± SD
Same drug comparisons
Arnold 1978 1
2
3
4
Placebo
MPH
DEX
Caffeine
Inattention:
Conners teacher
David's Hyperkinetic Rating Scale (parent)
David's Hyperkinetic Rating Scale (teacher)
Problem Behavior Checklist - parent

Hyperactivity:
Conners teacher
David's Hyperkinetic Rating Scale (parent)
David's Hyperkinetic Rating Scale (teacher)
Problem Behavior Checklist -- parent

Impulsivity:
David's Hyperkinetic Rating Scale (parent)
David's Hyperkinetic Rating Scale (teacher)

14. 62 ± 3.51
5.1 ± 0.86
5.07 ± 1.0
14.66 ± 3.98

22.52 ± 5.23
5.21 ± 0.82
5.03 ± 1.15
23.69 ± 5.87

4.97 ± 0.98
5.1 ± 1.01

12.1 ± 3.53
3.9 ± 1.01
3.97 ± 1.18
11.83 ± 3.79

16.83 ± 5.5
4.31 ± 1.23
3.83 ± 1.49
18.21 ± 5.61

4.1 ± 1.21
3.97 ± 1.28

12.03 ± 3.94
4.21 ± 0.94
3.79 ± 1.35
11.38 ± 3.39

16.17 ± 4.64
4.28 ± 1.07
3.9 ± 1.54
17.21 ± 5.45

4.17 ± 1.04
3.9 ± 1.42

14.24 ± 4.06
4.69 ± 0.93
5.07 ± 1.16
13.55 ± 4.95

21.66 ± 5.88
5.0 ± 0.89
4.93 ± 1.39
20.38 ± 6.34

4.83 ± 0.85
4.97 ± 1.15

NR
NR
NR
NR

NR
NR
NR
NR

NR
NR
Fitzpatrick 1992 1
2
3
4
Placebo
MPH-SR 0.67 mg/kg
MPH 0.56 mg/kg
MPH-SR 0.67 mg/kg + MPH 0.38 mg/kg
Inattention: Conners parent
Conners teacher
TOTS
Unspecified teacher report

Hyperactivity:
TOTS
Unspecified teacher report

1.9 ± 0.63
1.65 ± 039
0.36 ± 0.41
0.67 ± 0.62

0.7 ± 0.48
0.36 ± 0.69

0.98 ± 0.61
0.92 ± 0.68
0.72 ± 0.38
0.88 ± 0.62

0.22 ± 0.5
-0.12 ± 0.51

1.01 ± 0.46
0.87 ± 0.63
0.81 ± 0.41
1.01 ± 0.57

0.2 ± 0.31
-0.16 ± 0.44

0.79 ± 0.48
0.7 ± 0.56
0.91 ± 0344
1.05 ± 0.52

0.18 ± 0.49
-0.29 ± 0.56

"Dose group" > Placebo
"Dose group" > Placebo
"Dose group" > Placebo
"Dose group" > Placebo

"Dose group" > Placebo
"Dose group" > Placebo
Whitehouse 1980 1
2
MPH
MPH-SR
Inattention:
Unspecified teacher report
Hyperactivity:
Unspecified parent report
Unspecified teacher report
13 3

15 3
15 3
13 3

15 3
17 3

NS
NS
NS
Stimulant vs. stimulant comparisons
Arnold 1976 1
2
3
Placebo
DEX
L-Amph
Inattention:
Conners parent
Conners teacher
David's Hyperkinetic Rating Scale (parent)
David's Hyperkinetic Rating Scale (teacher)

Hyperactivity:
Conners parent
Conners teacher
David's Hyperkinetic Rating Scale (parent)
David's Hyperkinetic Rating Scale (teacher)

Impulsivity:
David's Hyperkinetic Rating Scale (parent)
David's Hyperkinetic Rating Scale (teacher)

14.65 ± 4.79
15.33 ± 3.83
4.52 ± 1.29
4.73 ± 1.55

20.81 ± 6.83
21.27 ± 5.63
4.58 ± 1.26
4.9 ± 1.3

4.87 ± 1.02
4.6 ± 1.3

11.9 ± 5.09
13.4 ± 4.26
3.84 ± 1.53
3.83 ± 1.62

16.68 ± 6.59
16.8 ± 5.54
3.97 ± 1.4
3.7 ± 1.49

4.06 ± 1.46
3.77 ± 1.41

12.19 ± 4.4
13.53 ± 4.46
4.13 ± 1.34
4.33 ± 1.45

18.39 ± 6.03
17.2 ± 5.76
4.32 ± 1.17
3.77 ± 1.45

4.39 ± 1.26
3.87 ± 1.41

NR
NR
NR
NR

NR
NR
NR
NR

NR
NR
Conners 1980 1
2
3
Placebo
MPH
Pemoline
Inattention:
Conners teacher

Hyperactivity:
Conners parent
Conners teacher

Impulsivity:
Conners parent

1.25 ± 0.73

0.75 ± 0.36
1.45 ± 0.63

1.31 ± 0.57

1.2 ± 0.73

0.46 ± 0.23
1.28 ± 0.67

0.69 ± 0.52

1.07 ± 0.42

0.41 ± 0.16
1.04 ± 0.52

0.7 ± 0.33

MPH, Pemoline vs. Placebo = NS

NS
NS

MPH, Pemoline > Placebo; MPH vs. Pemoline = NS
Stimulant vs. stimulant comparisons (cont.)
Conners 1972 1
2
3
Placebo
DEX
Pemoline
Inattention:
Conners teacher

Hyperactivity:
Conners parent
Conners teacher

Impulsivity:
Conners parent

9.8 3

13.4 3
13.3 3

19.1 3

6.4 3

10.6 3
6.2 3

11 3

7.7 3
10 3

9.8 3 13.2 3
DEX, Pemoline > Placebo; DEX vs. Pemoline = NS
DEX > Placebo; DEX, Placebo vs. Pemoline = NS
DEX, Pemoline > Placebo; DEX vs. Pemoline = NS DEX, Pemoline > Placebo; DEX vs. Pemoline = NS
Efron 1997 1
2
MPH
DEX
Inattention:
Conners teacher

Hyperactivity:
Conners teacher

Impulsivity:
Conners parent

54.09 ± 7.61

52.2 ± 11.0

57.39 ± 10.5

55.69 ± 8.9

58.88 ± 11.1

57.33 ± 11.2

MPH > DEX

MPH > DEX

NS
Elia 1991 1
2
3
Placebo
MPH
DEX
Hyperactivity:
Conners parent
Conners teacher

1.7 3
1.4 3

1 3
0.4 3

0.8 3
0.5 3

MPH, DEX > Placebo; MPH vs. DEX = NS
MPH, DEX > Placebo; MPH vs. DEX = NS
Matochik 1994 1
2
MPH
DEX
Inattention:
STESS

0.4 ± 0.6

0.6 ± 0.9

NR
Stimulant vs. tricyclic antidepressants
Quinn 1975 1
2
MPH
Imipramine
Hyperactivity:
Conners parent
Conners teacher

6.69 ± 3.59
8.3 ± 4.66

6.76 ± 3.74
8.07 ± 5.12

Imipramine vs. MPH = NS
Imipramine vs. MPH = NS
Werry 1980 1
2
3
Placebo
MPH
Imipramine
Inattention:
Conners teacher

Hyperactivity:
Conners parent
Conners teacher

2.14 3

1.17 3
2.56 3

1.95 3

1.29 3
2.22 3

2.02 3

1.04 3
2.34 3

NS

Imipramine > MPH
NS
1

Studies in this group with no data with outcomes of interest given are: Borcherding 1989 ; Castellanos 1997 ; Gross 1976 ; Kauffman 1981 ; Pelham 1987 ; Pelham 1990 ; Rapport 1993 ; Spring 1976 ; Srinivas 1992 ; Stephens 1984 ; Winsberg 1974.

2

> = better than; NS-not significant; NR-statistical significance not reported.

3

SD not given.

From: Supplemental Evidence Tables

Cover of Treatment of Attention-Deficit/Hyperactivity Disorder
Treatment of Attention-Deficit/Hyperactivity Disorder.
Evidence Reports/Technology Assessments, No. 11.
Jadad AR, Boyle M, Cunningham C, et al.

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