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Table 210.3Differential Diagnosis of Weight Loss

Decreased intake
Malignancy (esp. pulmonary, lymphoma, GI, renal)
Chronic debilitating diseases (esp. severe COPD, CHF, rheumatoid arthritis)
Mouth and throat disorders (e.g., poor dentition, stomatitis)
Esophageal obstruction (e.g., achalasia)
Gastric ulcer made worse with food
Duodenal ulcer with outlet obstruction
Liver disease (e.g., advanced cirrhosis)
Renal failure
Infections (e.g., tuberculosis)
Endocrine disorders (e.g., Addison's disease, hypopituitarism)
Drugs (e.g., digitalis, antineoplastic agents) and alcohol
Psychoneurologic (e.g., anorexia nervosa, bulemia, depression, stroke, CNS neoplasm)
Decreased absorption
Postgastrectomy syndrome
Intestinal disease (e.g., Crohn's disease, ulcerative colitis)
Cholestatic disease
Pancreatic exocrine disease
Infections (e.g., giardiasis)
Diabetic enteropathy
Drugs
Increased metabolic requirements
Hyperthyroidism
Pheochromocytoma
Major surgery
Fever
Mania
Increased output
Diabetes mellitus
Chronic vomiting, diarrhea, bleeding
Fistulous or catheter drainage
Nephrotic syndrome

From: Chapter 210, Weight Change

Cover of Clinical Methods
Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.
Walker HK, Hall WD, Hurst JW, editors.
Boston: Butterworths; 1990.
Copyright © 1990, Butterworth Publishers, a division of Reed Publishing.

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