Figure 5-29. Two families of molecular chaperones.

Figure 5-29Two families of molecular chaperones

The hsp70 proteins act early, recognizing small patches on a protein's surface. The hsp60-like proteins appear to act later and form a container into which proteins that have still failed to fold are transferred. In both cases repeated cycles of ATP hydrolysis by the hsp proteins contribute to a cycle of binding and release of the client protein that helps this protein to fold.

From: The Birth, Assembly, and Death of Proteins

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 3rd edition.
Alberts B, Bray D, Lewis J, et al.
New York: Garland Science; 1994.
Copyright © 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D Watson.

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