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Transport from early to the late endosome is mediated by large endosomal carrier vesicles, which contain large amounts of invaginated membrane and are therefore called multivesicular bodies. It is uncertain whether they should be regarded as middle-aged endosomes moving toward the cell interior as they mature or as distinct transport compartments. The movement occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. Eventually, the late endosome is thought to convert into a lysosome. Transport vesicles recycle material between the early endosome and the cell surface, while a different set of transport vesicles recycle material between the late endosome and the trans Golgi network.