Table 46-1Data Supporting Early Endosomes as the Principal Site of Aβ Generation

Deleting β-amyloid precursor protein (βAPP) cytoplasmic domain (GYENPTY) lowers amyloid β protein () production
Mild alkalinization lowers production
Altering vesicular H+ transport lowers production
Late endosome/lysosome fractions do not contain
Endocytosis of surface-labeled βAPP molecules leads directly to release of labeled
Kinetics of labeled release are slightly slower than those of APPs and consistent with those of recycling endosomes
Depleting cellular K+ inhibits clathrin-mediated endocytosis and lowers production

From: Alzheimer's Disease Is the Most Common Neurodegenerative Disorder

Cover of Basic Neurochemistry
Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition.
Siegel GJ, Agranoff BW, Albers RW, et al., editors.
Philadelphia: Lippincott-Raven; 1999.
Copyright © 1999, American Society for Neurochemistry.

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