Figure 5. Physiological characteristics of intrinsic photosensitivity in ipRGCs.

Figure 5

Physiological characteristics of intrinsic photosensitivity in ipRGCs. (a) Current clamp recording from an ipRGC showing depolarizing response with spiking and slow response kinetics. (b) Comparison of action spectra for rod and cone photoreceptors with that of ipRGCs. (c) Whole-cell recording from an ipRGC showing changes in response amplitude with increasing levels of illumination. (d) Plot of response amplitude versus light intensity for 3 separate ipRGCs. Adapted from Berson DM, Dunn FA, et al. (2002). "Phototransduction by retinal ganglion cells that set the circadian clock." Science. 295(5557): 1070-3 and Berson DM (2003). "Strange vision: ganglion cells as circadian photoreceptors." Trends Neurosci. 26(6): 314-20.

From: Melanopsin Ganglion Cells: A Bit of Fly in the Mammalian Eye

Cover of Webvision
Webvision: The Organization of the Retina and Visual System [Internet].
Kolb H, Fernandez E, Nelson R, editors.
Salt Lake City (UT): University of Utah Health Sciences Center; 1995-.

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