Figure 3.6. There are discrete regions of hypervariability in V domains.

Figure 3.6There are discrete regions of hypervariability in V domains

A variability plot derived from comparison of the amino acid sequences of several dozen heavy-chain and light-chain V domains. At each amino acid position the degree of variability is the ratio of the number of different amino acids seen in all of the sequences together to the frequency of the most common amino acid. Three hypervariable regions (HV1, HV2, and HV3) are indicated in red and are also known as the complementarity-determining regions, CDR1, CDR2, and CDR3. They are flanked by less variable framework regions (FR1, FR2, FR3, and FR4, shown in blue or yellow).

From: The interaction of the antibody molecule with specific antigen

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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