Figure 5.17. Two modes of crossreactive recognition that may explain alloreactivity.

Figure 5.17Two modes of crossreactive recognition that may explain alloreactivity

A T cell that is specific for one peptide:MHC combination (left panel) may cross-react with peptides presented by other, nonself (allogeneic), MHC molecules. This may come about in either of two ways. Most commonly, the peptides bound to the allogeneic MHC molecule fit well to the T-cell receptor (TCR), allowing binding even if there is not a good fit with the MHC molecule (center panel). Alternatively, but less often, the allogeneic MHC molecule may provide a better fit to the T-cell receptor, giving a tight binding that is thus less dependent on the peptide that is bound to the MHC molecule (right panel).

From: The major histocompatibility complex and its functions

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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