Figure 9.9. Antigen-binding cells are trapped in the T-cell zone.

Figure 9.9Antigen-binding cells are trapped in the T-cell zone

Upon entry into lymphoid tissues through a high endothelial venule (HEV), T cells and B cells home to different regions, as described in Chapter 7. Antigen-specific T cells remain in the T-cell zone provided that they encounter antigen on the surface of a antigen-presenting cell such as a dendritic cell. B cells normally move rapidly through the T-cell zone, unless they bind specific antigen, in which case they are trapped before leaving the T-cell zone and thus can interact with antigen-specific armed helper T cells. This interaction gives rise to a primary focus of B cells and T cells near the border between B-cell and T-cell zones.

From: B-cell activation by armed helper T cells

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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