Figure 4.17. The structural organization of the main human immunoglobulin isotype monomers.

Figure 4.17The structural organization of the main human immunoglobulin isotype monomers

Both IgM and IgE lack a hinge region but each contains an extra heavy-chain domain. Note the differences in the numbers and locations of the disulfide bonds (black lines) linking the chains. The isotypes also differ in the distribution of N-linked carbohydrate groups, shown as turquoise hexagons.

From: Structural variation in immunoglobulin constant regions

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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