Figure 2.5. Phagocytes bear several different receptors that recognize microbial components and induce phagocytosis.

Figure 2.5Phagocytes bear several different receptors that recognize microbial components and induce phagocytosis

The figure illustrates five such receptors on macrophages—CD14, CD11b/CD18 (CR3), the macrophage mannose receptor, the scavenger receptor, and the glucan receptor, all of which bind bacterial carbohydrates. CD14 and CR3 are specific for bacterial lipopolysaccharide (LPS). The designation CD stands for ‘cluster of differentiation,’ a historical term that was coined to define cell-surface molecules that are recognized by a given set of monoclonal antibodies. This ‘cluster of differentiation’ then received a number, for example CD4, which stands only for the order of discovery. In general, each CD is associated with one or more functions, which were discovered through the effects on cell or tissue function of the antibodies that defined it. See Appendix II for a full listing of CDs.

From: The front line of host defense

Cover of Immunobiology
Immunobiology: The Immune System in Health and Disease. 5th edition.
Janeway CA Jr, Travers P, Walport M, et al.
New York: Garland Science; 2001.
Copyright © 2001, Garland Science.

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