Figure 4. A model for the behavior of chromatin proteins during embryonic stem cell differentiation.

Figure 4A model for the behavior of chromatin proteins during embryonic stem cell differentiation.

A. In undifferentiated ES cells, a fraction of chromatin proteins, including histones and HP1, are loosely bound or unbound, likely contributing to the pluripotent state. B. During differentiation, chromatin proteins bind tightly to chromatin, establishing heterochromatin domains during differentiation.

From: Imaging chromatin in embryonic stem cells

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StemBook [Internet].
Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Copyright: © 2008 Eran Meshorer.

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