Figure 1. Schematic representation of selective migration of MSCs to areas of tissue injury and tumours where they contribute to tissue repair and tumour-associated stroma formation.

Figure 1Schematic representation of selective migration of MSCs to areas of tissue injury and tumours where they contribute to tissue repair and tumour-associated stroma formation.

(1) Lung injury stimulates MSC activation via interaction of SDF-1 with its receptor CXCR4. Acting in an autocrine fashion SDF-1 causes increased migration, survival and proliferation of MSCs. (2) Activated MSCs migrate to areas of injury and tumour in response to SDF-1.

From: The role of bone marrow-derived stem cells in lung regeneration and repair

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StemBook [Internet].
Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Copyright: © 2008 Elizabeth K. Sage, Michael R. Loebinger, Julia Polak and Sam M. Janes.

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