Figure 1. Proposed pathways of interaction between transplanted hESC derivatives and the immune system.

Figure 1Proposed pathways of interaction between transplanted hESC derivatives and the immune system.

T cells recognize alloantigens by two distinct pathways known as the direct and indirect. (A) Direct allorecognition occurs when recipient T cells recognize intact allogeneic MHC molecules (together with bound endogenous peptide) on the surface of donor APCs, such as DCs (left). FasL expression on target cells (mainly in immunoprivileged sites) can prevent immune responses by inducing apoptosis in Fas-bearing leukocytes (right). (B) During indirect allorecognition, host APCs process donor derived proteins, primarily MHCs and present them in self-MHC molecules to recipient T cells. (A, B) Co-stimulatory interaction between CD80/CD86 molecules on APCs with their receptor CD28 on T cells is essential for sensitization and propagation of immune responses. TCR T cell receptor.

From: Immunological considerations for cell therapy using human embryonic stem cell derivatives

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StemBook [Internet].
Cambridge (MA): Harvard Stem Cell Institute; 2008-.
Copyright: © 2008 Micha Drukker.

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