Figure 18-3. The related structure and function of cohesins and condensins.

Figure 18-3The related structure and function of cohesins and condensins

(A) Both proteins have two identical DNA- and ATP-binding domains at one end and a hinge region at the other, joined by two, long, coiled-coil regions. This flexible structure is well suited for their role as DNA cross-linkers. (B) Cohesins cross-link two adjacent sister chromatids, gluing them together. (C) Condensins mediate intramolecular cross-linking to coil DNA in the process of chromosome condensation. (Adapted from T. Hirano, Genes and Dev. 13:11–19, 1999.)

From: An Overview of M Phase

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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