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Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002.

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Cover of Molecular Biology of the Cell

Molecular Biology of the Cell. 4th edition.

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Figure 22-53. An osteoclast shown in cross section.

Figure 22-53An osteoclast shown in cross section

This giant, multinucleated cell erodes bone matrix. The “ruffled border” is a site of secretion of acids (to dissolve the bone minerals) and hydrolases (to digest the organic components of the matrix). Osteoclasts vary in shape, are motile, and often send out processes to resorb bone at multiple sites. They develop from monocytes and can be viewed as specialized macrophages. (From R.V. Krstic´, Ultrastructure of the Mammalian Cell: An Atlas. Berlin: Springer-Verlag, 1979.)

From: Fibroblasts and Their Transformations: The Connective-Tissue Cell Family

Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .


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