Figure 13-50. The sequestration of endocytosed proteins into internal membranes of multivesicular bodies.

Figure 13-50The sequestration of endocytosed proteins into internal membranes of multivesicular bodies

Eventually, all of the internal membranes produced by the invaginations shown are digested by proteases and lipases in lysosomes. The invagination is essential to achieve complete digestion of endocytosed membrane proteins. Because the outer membrane of the multivesicular body becomes continuous with the lysosomal membrane, lysosomal hydrolases could not digest the cytosolic domains of transmembrane proteins such as the EGF receptor shown here, if it were not for the invagination.

From: Transport into the Cell from the Plasma Membrane: Endocytosis

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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