Figure 13-11. The postulated role of SNAREs in guiding vesicular transport.

Figure 13-11The postulated role of SNAREs in guiding vesicular transport

Complementary sets of vesicle SNAREs (v-SNAREs) and target membrane SNAREs (t-SNAREs) contribute to the selectivity of transport-vesicle docking and fusion. The v-SNAREs are packaged together with the coat proteins during the budding of transport vesicles from the donor membrane and bind to complementary t-SNAREs in the target membrane. After fusion, the v- and t-SNAREs remain associated in a tight complex. The complexes have to be dissociated before the t-SNAREs can accept a new vesicle or the v-SNAREs can be recycled to the donor compartment for participation in a new round of vesicular transport. As shown here, different v-SNAREs can be packaged with different cargo molecules (through association with other proteins; not shown) when leaving the donor compartment. In this case, the two sets of cargo will be delivered to different t-SNAREs and therefore to different target membranes.

From: The Molecular Mechanisms of Membrane Transport and the Maintenance of Compartmental Diversity

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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