Table 5-1The Three Steps That Give Rise to High-Fidelity DNA Synthesis

5′→3′ polymerization1 × 105
3′→5′ exonucleolytic proofreading1 × 102
Strand-directed mismatch repair1 × 102
Total1 × 109

The third step, strand-directed mismatch repair, is described later in this chapter.

From: DNA Replication Mechanisms

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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