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Table 24-4Properties of Some Interleukins

CYTOKINESOME SOURCESSOME TARGETSSOME ACTIONS
IL-2all helper T cells; some cytotoxic T cells; activated mast cellsall activated T cells and B cellsstimulates proliferation and differentiation
IL-4TH2 cells and mast cellsB cells and TH cellsstimulates B cell proliferation, maturation, and class switching to IgE and IgG1; inhibits TH1 cell development
IL-5TH2 cells and mast cellsB cells, eosinophilspromotes proliferation and maturation
IL-10TH2 cells, macrophages, and dendritic cellsmacrophages and TH1 cellsinhibits macrophages and TH1 cell development
IL-12B cells, macrophages, and dendritic cellsnaïve T cellsinduces TH2 cell development and inhibits TH1 cell development
IFN-γTH1 cellsB cells, macrophages, endothelial cellsactivates various MHC genes and macrophages; increases MHC expression in many cell types
TNF-αTH1 cells and macrophagesendothelial cellsactivates

From: Helper T Cells and Lymphocyte Activation

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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