Figure 15-55. The activation of Ras by an activated receptor tyrosine kinase.

Figure 15-55The activation of Ras by an activated receptor tyrosine kinase

Most of the signaling proteins bound to the activated receptor are omitted for simplicity. The Grb-2 adaptor protein binds to a specific phosphotyrosine on the receptor and to the Ras guanine nucleotide exchange factor (GEF), which stimulates Ras to exchange its bound GDP for GTP. The activated Ras then activates several downstream signaling pathways, one of which is shown in Figure 15-56.

From: Signaling through Enzyme-Linked Cell-Surface Receptors

Cover of Molecular Biology of the Cell
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Copyright © 2002, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter; Copyright © 1983, 1989, 1994, Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson .

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